ArticleThe Journal of the Acoustical Society of America2014
Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound.
Article in The Journal of the Acoustical Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Enhanced thrombolytic effect induced by acoustic cavitation generated from nitrogen-doped annealed nanodiamond particles.Ultrasonics sonochemistry · 2023Article
- Assessment of bubble activity generated by histotripsy combined with echogenic liposomes.Physics in medicine and biology · 2022Article
- Cavitation Emissions Nucleated by Definity Infused through an EkoSonic Catheter in a Flow Phantom.Ultrasound in medicine & biology · 2021Article
- The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro.Physics in medicine and biology · 2019Article
- For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy.Ultrasound in medicine & biology · 2019Review
- Characterization of cavitation-radiated acoustic power using diffraction correction.The Journal of the Acoustical Society of America · 2018Article
- Ultrasound-guided intertumoral injection of contrast agents combined with human p53 gene for the treatment of breast cancer.The Kaohsiung journal of medical sciences · 2018Article
- Closed-loop control of targeted ultrasound drug delivery across the blood-brain/tumor barriers in a rat glioma model.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- In vitro thrombolytic efficacy of echogenic liposomes loaded with tissue plasminogen activator and octafluoropropane gas.Physics in medicine and biology · 2017Article
- Article
- Superharmonic microbubble Doppler effect in ultrasound therapy.Physics in medicine and biology · 2016Article
- Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes.Journal of thrombosis and thrombolysis · 2015Article
- Shaken and stirred: mechanisms of ultrasound-enhanced thrombolysis.Ultrasound in medicine & biology · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Ultrasound contrast agents (UCAs) can be employed to nucleate cavitation to achieve desired bioeffects, such as thrombolysis, in therapeutic ultrasound applications. Effective methods of enhancing thrombolysis with ultrasound have been examined at low frequencies (<1 MHz) and low amplitudes (<0.5 MPa). The objective of this study was to determine cavitation thresholds for two UCAs exposed to 120-kHz ultrasound. A commercial ultrasound contrast agent (Definity(®)) and echogenic liposomes were investigated to determine the acoustic pressure threshold for ultraharmonic (UH) and broadband (BB) generation using an in vitro flow model perfused with human plasma. Cavitation emissions were detected using two passive receivers over a narrow frequency bandwidth (540-900 kHz) and a broad frequency bandwidth (0.54-1.74 MHz). UH and BB cavitation thresholds occurred at the same acoustic pressure (0.3 ± 0.1 MPa, peak to peak) and were found to depend on the sensitivity of the cavitation detector but not on the nucleating contrast agent or ultrasound duty cycle.
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