Evidence map›Paper›PMID 25234626›Full record

ArticleDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete2014

[Tricky cases in in-vitro diagnostics of hymenoptera venom allergy].

S Müller, D Rafei-Shamsabadi, T Jakob

Abstract readEnglish Abstract
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In one paragraph

Article in Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

S MüllerAllergieabteilung und Forscherguppe Allergologie, Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland, sabine.mueller.hautklinik@uniklinik-freiburg.de.
D Rafei-Shamsabadi
T Jakob

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHymenoptera stings give rise to anaphylactic reactions in 1.2-3.5 % of the population. The risk of repeat anaphylaxis following subsequent stings is greatly reduced through immunotherapy with the culprit venom. A prerequisite for allergen-specific immunotherapy is a precise diagnostic work-up. AIMS AND

objectivesWe review the efficacy of currently available in-vitro diagnostic tests for hymenoptera venom allergy in different clinical scenarios.

methodsA targeted literature review in PubMed and a review of the current guideline on hymenoptera venom allergy were performed. For illustrative purposes, a series of clinical cases from our allergy department are presented. RESULTS AND

conclusionThe correct diagnosis in hymenoptera venom allergy is influenced by a number of factors including patients' ability to identify the insect and time lapsed to diagnostic tests. The high rate of clinically irrelevant sensitizations, cross-reactivity and suboptimal sensitivity of the currently available diagnostic tests further complicate the picture. In the case of multiple sensitizations, molecular allergy diagnostics has improved the detection of clinically relevant sensitizations allowing the cost and risks of unnecessary double immunotherapy to be avoided. This is true in particular with regard to wasp venom allergy. For bee venom allergy, improvements in molecular allergy diagnostics have shown promising results and their implementation in clinical practice is planned. In patients with no sensitization in skin or serological tests but with a convincing history of insect sting anaphylaxis, the increased sensitivity of a basophil activation test may deliver crucial evidence of venom sensitization. The value of the basophil activation test may be further improved using specific marker allergens. The diagnosis of allergy to paper wasps (Polistinae) and white-faced hornets (Dolichovespula) remains problematic as they show partial cross-reactivity to wasp venom and specific marker allergens particular to these, still have to be identified.

Indexed as

AnimalsBasophil Degranulation TestBee VenomsDiagnosis, DifferentialHumansInsect Bites and StingsMolecular Diagnostic TechniquesSerologic TestsWasp VenomsBee VenomsWasp Venoms

Identifiers

PMID25234626

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