Evidence map›Paper›PMID 25234368›Full record

ArticleBMC infectious diseases2014

Current drug use and lack of HIV virologic suppression: point-of-care urine drug screen versus self-report.

Han-Zhu Qian, Valerie J Mitchell, Sally Bebawy, Holly Cassell, Gina Perez, Catherine C McGowan, Timothy R Sterling, Sten H Vermund, Richard D'Aquila, Todd Hulgan

Abstract read
In one paragraph

Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Barriers to HIV testing, linkage to care, and treatment adherence: a cross-sectional study from a large urban center of Brazil.Revista panamericana de salud publica = Pan American journal of public health · 2016
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Han-Zhu QianVanderbilt Institute for Global Health, Vanderbilt University, Nashville, Tennessee, USA. han-zhu.qian@vanderbilt.edu.
Valerie J Mitchell
Sally Bebawy
Holly Cassell
Gina Perez
Catherine C McGowan
Timothy R Sterling
Sten H Vermund
Richard D'Aquila
Todd Hulgan

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jin Chen · 1995 to 2026
$172.8M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
VIROLOGY COREP30AI054999 · NIAID · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 2003 to 2011
$10.3M
NCI NIH HHS P30 CA068485NCI NIH HHS P30CA068485NCRR NIH HHS 1 UL1 RR024975NCRR NIH HHS UL1 RR024975NIAID NIH HHS P30 AI054999NIAID NIH HHS P30 AI 54999
6 · The paper itself

Abstract

backgroundThere have been inconsistent findings on the association between current drug use and HIV disease progression and virologic suppression. Drug use was often measured using self-report of historical use. Objective measurement of current drug use is preferred.

methodsIn this cross-sectional study, we assessed drug use through Computer-Assisted Self Interviews (CASI) and point-of-care urine drug screen (UDS) among 225 HIV-infected patients, and evaluated the association between current drug use and virologic suppression.

resultsAbout half (54%) of participants had a positive UDS, with a lower self-reported rate by CASI (42%) (Kappa score = 0.59). By UDS, 36.0% were positive for marijuana, 25.8% for cocaine, 7.6% for opiates, and 2.2% for methamphetamine or amphetamine. Factors associated with virologic suppression (plasma HIV RNA <50 copies/mL) were Caucasian race (P = 0.03), higher CD4 count (P < 0.01), current use of antiretroviral therapy (ART) (P < 0.01), and a negative UDS (P < 0.01). Among 178 current ART users, a positive UDS remained significantly associated with lower likelihood of virologic suppression (P = 0.04).

conclusionsUDS had good agreement with CASI in detecting frequently used drugs such as marijuana and cocaine. UDS at routine clinic visits may provide "real-time" prognostic information to optimize management.

Indexed as

AdultAgedAnti-HIV AgentsCD4 Lymphocyte CountCross-Sectional StudiesDisease ProgressionDrug UsersFemaleHIV-1HIV InfectionsHumansIllicit DrugsInterviews as TopicMaleMiddle AgedPoint-of-Care SystemsAnti-HIV AgentsIllicit Drugs

Identifiers

PMID25234368
PMCPMC4175271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.