Evidence map›Paper›PMID 25234213›Full record

ArticleThe journal of evidence-based dental practice2014

The multi-center randomized controlled trial (RCT) published by the journal of the American Medical Association (JAMA) on the effect of periodontal therapy on glycated hemoglobin (HbA1c) has fundamental problems.

Wenche S Borgnakke, Iain L C Chapple, Robert J Genco, Gary Armitage, P Mark Bartold, Francesco D'Aiuto, Paul I Eke, William V Giannobile, Thomas Kocher, Kenneth S Kornman and 11 more

Registry-linked trialAbstract readComment
In one paragraph

Article in The journal of evidence-based dental practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04830969 (Impact of Periodontal Therapy on Patients With Diabetes), which is not on this map. Cited by 18 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04830969 phase2completednot on this mapstarted 2016, after this paper: background citation

Impact of Periodontal Therapy on Patients With Diabetes: A Pilot Study

TypeinterventionalSponsorState University of New York at BuffaloRan2016 to 2021Enrolled116ConditionsDiabetes Mellitus, Type II, PeriodontitisArmsChlorhexidine gluconate oral rinse, Scaling & Root Planing, Soft Picks
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Antibiotic effects against periodontal bacteria in organ cultured tissue.Clinical and experimental dental research · 2017
    Article
  15. Article
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Wenche S BorgnakkeDepartment of Periodontics and Oral Medicine University of Michigan School of Dentistry 1011 North University Avenue Rm# G049 Ann Arbor MI 48109-1078 USA Tel.: +1 734 478 1233 (mobile). Electronic address: wsb@umich.edu.
Iain L C ChappleProfessor of Periodontology and Consultant in Restorative Dentistry, Periodontal Research Group & MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, St Chad's Queensway, Birmingham B4 6NN United Kingdom Tel.: +44 (0)121 466 5486. Electronic address: I.L.C.Chapple@bham.ac.uk.
Robert J Genco
Gary Armitage
P Mark Bartold
Francesco D'Aiuto
Paul I Eke
William V Giannobile
Thomas Kocher
Kenneth S Kornman
Niklaus P Lang
Phoebus N Madianos
Shinya Murakami
Fusanori Nishimura
Steven Offenbacher
Philip M Preshaw
Amin Ur Rahman
Mariano Sanz
Jørgen Slots
Maurizio S Tonetti
Thomas E Van Dyke

Funding

Diabetes and Periodontics Trial - Administrative Center/Study ChairU01DE018902 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI ENGEBRETSON, STEVEN P · 2008 to 2012
$11.1M
Diabetes and Periodontics Trial - Coordinating CenterU01DE018886 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI HYMAN, LESLIE G · 2008 to 2012
$4.3M
Neutrophils and Periodontitis in DiabetesR01DE015566 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI VAN DYKE, THOMAS ELLIOTT · 2005 to 2014
$4.2M
NIDCR NIH HHS R01 DE015566NIDCR NIH HHS U01 DE018886NIDCR NIH HHS U01 DE018902
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Dental ScalingRoot PlaningChronic PeriodontitisDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansMaleGlycated Hemoglobin

Identifiers

PMID25234213
PMCPMC4502578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.