ArticleAging cell2014
Growth hormone signaling is necessary for lifespan extension by dietary methionine.
Article in Aging cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial.Journal of translational medicine · 2024Trial
- Methionine restriction and mimetics to ameliorate human aging and disease.Trends in endocrinology and metabolism: TEM · 2026Review
- The Fifth Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Long term methionine restriction: Influence on gut microbiome and metabolic characteristics.Aging cell · 2024Article
- Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction.Aging biology · 2024Article
- Too old for healthy aging? Exploring age limits of longevity treatments.npj metabolic health and disease · 2024Review
- Amino acid restriction, aging, and longevity: an update.Frontiers in aging · 2024Review
- Sexually dimorphic effects of methionine sulfoxide reductase A (MsrA) on murine longevity and health span during methionine restriction.GeroScience · 2023Article
- Dietary regulation in health and disease.Signal transduction and targeted therapy · 2022Review
- Intermittent methionine restriction reduces IGF-1 levels and produces similar healthspan benefits to continuous methionine restriction.Aging cell · 2022Article
- Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA).Scientific reports · 2022Article
- Impacts of essential amino acids on energy balance.Molecular metabolism · 2022Review
- Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.Cell metabolism · 2021Review
- Hydrogen sulfide in ageing, longevity and disease.The Biochemical journal · 2021Review
- Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age.Pituitary · 2021Review
- Article
- Mouse models of growth hormone deficiency.Reviews in endocrine & metabolic disorders · 2021Review
- Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice.Nature aging · 2021Article
- Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats.Aging cell · 2020Article
- Perspective: Methionine Restriction-Induced Longevity-A Possible Role for Inhibiting the Synthesis of Bacterial Quorum Sensing Molecules.Advances in nutrition (Bethesda, Md.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Growth hormone significantly impacts lifespan in mammals. Mouse longevity is extended when growth hormone (GH) signaling is interrupted but markedly shortened with high-plasma hormone levels. Methionine metabolism is enhanced in growth hormone deficiency, for example, in the Ames dwarf, but suppressed in GH transgenic mice. Methionine intake affects also lifespan, and thus, GH mutant mice and respective wild-type littermates were fed 0.16%, 0.43%, or 1.3% methionine to evaluate the interaction between hormone status and methionine. All wild-type and GH transgenic mice lived longer when fed 0.16% methionine but not when fed higher levels. In contrast, animals without growth hormone signaling due to hormone deficiency or resistance did not respond to altered levels of methionine in terms of lifespan, body weight, or food consumption. Taken together, our results suggest that the presence of growth hormone is necessary to sense dietary methionine changes, thus strongly linking growth and lifespan to amino acid availability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.