Evidence map›Paper›PMID 25234079›Full record

ReviewSeminars in nuclear medicine2014

Cardiac PET perfusion: prognosis, risk stratification, and clinical management.

Sharmila Dorbala, Marcelo F Di Carli

Registry-linked trialAbstract readReview
In one paragraph

Review in Seminars in nuclear medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04475094 (Impact of Coronary Artery Stenting on Quantitative Myocardial Blood Flow and Health Status), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04475094 unknown statusnot on this mapstarted 2019, after this paper: background citation

Impact of Coronary Artery Stenting on Quantitative Myocardial Blood Flow and Health Status

TypeobservationalSponsorCardiovascular Imaging TechnologiesRan2019 to 2021Enrolled75ConditionsCoronary Artery DiseaseArmsRubidium-82, Seattle Angina Questionnaire-7, Rose Dyspnea Scale
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Revisiting Perfusion in the Forgotten Right Ventricle: Artificial Intelligence-Enhanced Quantification on PET/CT.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  5. Combined perfusion and metabolic imaging of small cell lung cancer with dual-isotope LAFOV-PET.European journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA).Journal of the Society for Cardiovascular Angiography & Interventions · 2024
    Review
  12. Review
  13. Review
  14. Coronary vasculopathy due to moyamoya disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  15. Article
  16. Article
  17. Severe myocardial stunning after myocardial perfusion on gated SPECT exercise stress test.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  18. Development, diagnostic performance, and interobserver agreement of aJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sharmila DorbalaNoninvasive Cardiovascular Imaging Program, Heart and Vascular Center, Department of Radiology; Department of Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address: sdorbala@partners.org.
Marcelo F Di CarliNoninvasive Cardiovascular Imaging Program, Heart and Vascular Center, Department of Radiology; Department of Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Funding

Prognostic Utility of Absolute Coronary Microvascular Function by PET/CTK23HL092299 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DORBALA, SHARMILA · 2009 to 2013
$705k
NHLBI NIH HHS K23 HL092299
6 · The paper itself

Abstract

Myocardial perfusion imaging (MPI) with PET has expanded significantly over the past decade. With the wider availability of PET scanners and the routine use of quantitative blood flow imaging, the clinical use of PET MPI is expected to increase further. PET MPI is a powerful tool to identify risk, to quantify risk, and to guide therapy in patients with known or suspected coronary artery disease. A large body of evidence supports the prognostic value of PET MPI and ejection fraction in intermediate- to high-risk subjects, in women, in obese individuals, and in post-coronary artery bypass grafting individuals. A normal perfusion study indicates low risk (<1% annualized rate of cardiac events of cardiac death and non-fatal myocardial infarction), while an abnormal study indicates high risk. With accurate risk stratification, high-quality images, and quantitation, PET MPI may transform the management of patients with known or suspected coronary artery disease.

Indexed as

Coronary Artery DiseaseDecision MakingHumansMyocardial Perfusion ImagingPositron-Emission TomographyPrognosisRisk Assessment

Identifiers

PMID25234079
PMCPMC4176813

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.