Evidence map›Paper›PMID 25233938›Full record

ArticleEpidemiology and infection2015

Toxins and virulence factors of enterotoxigenic Escherichia coli associated with strains isolated from indigenous children and international visitors to a rural community in Guatemala.

O R Torres, W González, O Lemus, R A Pratdesaba, J A Matute, G Wiklund, D A Sack, A L Bourgeois, A-M Svennerholm

Open access · hybridAbstract read
In one paragraph

Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Epidemiological and Clinical Features of EnterotoxigenicOpen forum infectious diseases · 2025
    Article
  3. Efficacy of an EnterotoxigenicMicroorganisms · 2023
    Article
  4. Article
  5. Article
  6. Development of an enterotoxigenicHuman vaccines & immunotherapeutics · 2019
    Review
  7. The Coli Surface Antigen CS3 of EnterotoxigenicFrontiers in microbiology · 2019
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

O R TorresInstitute for Nutrition in Central America and Panama (INCAP),Guatemala City,Guatemala.
W GonzálezInstitute for Nutrition in Central America and Panama (INCAP),Guatemala City,Guatemala.
O LemusUniversidad de San Carlos de Guatemala,Facultad de Ciencias Quimicas y Farmacia,Escuela de Quimica Biologica,Guatemala City,Guatemala.
R A PratdesabaInstitute for Nutrition in Central America and Panama (INCAP),Guatemala City,Guatemala.
J A MatuteCentro de Investigaciones en Nutrición y Salud (CIENSA),Guatemala City,Guatemala.
G WiklundDepartment of Microbiology and Immunology,University of Gothenburg,Gothenburg,Sweden.
D A SackJohns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.
A L BourgeoisJohns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.
A-M SvennerholmDepartment of Microbiology and Immunology,University of Gothenburg,Gothenburg,Sweden.
Johns Hopkins University · USUniversity of San Carlos of Guatemala · GT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diarrhoea remains a common cause of illness in Guatemala, with children suffering most frequently from the disease. This study directly compared the frequency, enterotoxin, and colonization factor (CF) profiles of enterotoxigenic Escherichia coli (ETEC) strains isolated from children living in a rural community in Guatemala and from Western visitors to the same location during the same seasons, using similar detection methodologies. We found that ETEC accounted for 26% of severe cases of diarrhoea in children requiring hospitalization, 15% of diarrhoea in the community, and 29% of travellers' diarrhoea in visitors staying ⩾2 weeks. The toxin and CF patterns of the ETEC strains isolated from both groups differed significantly (P < 0·0005) as determined by χ 2 = 60·39 for CFs and χ 2 = 35 for toxins, while ETEC phenotypes found in Guatemalan children were comparable to those found in children from other areas of the world.

Indexed as

TravelAdultBacterial ToxinsChild, PreschoolDiarrheaEnterotoxigenic Escherichia coliEnterotoxinsEscherichia coli InfectionsEscherichia coli ProteinsGuatemalaHumansInfantPopulation GroupsRural PopulationVirulence FactorsBacterial ToxinsEnterotoxinsEscherichia coli Proteinsheat-labile enterotoxin, E coliheat stable toxin (E coli)Virulence Factorstravellers' infection

Identifiers

PMID25233938
PMCPMC4416357
OpenAlexW2109093698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.