Observational studyBMC pulmonary medicine2014
Non specific pattern of lung function in a respiratory physiology unit: causes and prevalence: results of an observational cross-sectional and longitudinal study.
Observational study in BMC pulmonary medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Rectifying COPD management: a critical analysis of the Global Initiative for Chronic Obstructive Lung Disease strategy.ERJ open research · 2026Review
- The utility of spirometry and single breath gas transfer measurements to identify low total lung capacity.ERJ open research · 2025Article
- Late-onset pulmonary complications following allogeneic hematopoietic cell transplantation in pediatric patients: a prospective multicenter study.Bone marrow transplantation · 2024Article
- Predicting total lung capacity from spirometry: a machine learning approach.Frontiers in medicine · 2023Article
- Forced expiratory time: a composite of airway narrowing and airway closure.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Article
- Physiologic Insights from the COPD Genetic Epidemiology Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Review
- Joint Indian Chest Society-National College of Chest Physicians (India) guidelines for spirometry.Lung India : official organ of Indian Chest Society · 2019Article
- Subclinical pulmonary dysfunction contributes to high altitude pulmonary edema susceptibility in healthy non-mountaineers.Scientific reports · 2017Article
- Article
- Bronchodilator Response Assessment of the Small Airways Obstructive Pattern.The open respiratory medicine journal · 2017Article
- The physiological basis and clinical significance of lung volume measurements.Multidisciplinary respiratory medicine · 2017Review
- Different KCO and VA combinations exist for the same DLCO value in patients with diffuse parenchymal lung diseases.BMC pulmonary medicine · 2015Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundATS/ERS Task Force has highlighted that special attention must be paid when FEV1 and FVC are concomitantly decreased (<5th percentile) and the FEV1/FVC ratio is normal (>5th percentile) because a possible cause of this non specific pattern (NSP) is collapse of small airways with normal TLC measured by body plethysmography (>5th percentile). Our objectives were to determine the main lung diseases associated with this pattern recorded prospectively in a lung function testing (LFT) unit, the prevalence of this pattern in our LFT and among the diseases identified, and its development.
methodsObservational study of routinely collected data selected from our Clinical Database Warehouse.
resultsThe prevalence of NSP was 841/12 775 tests (6.6%, 95% CI: 6.2 to 7.0%). NSP was mainly associated with seven lung diseases: asthma (prevalence of NSP among asthmatics: 12.6%), COPD/emphysema (prevalence 8.6%), bronchiectasis (12.8%), sarcoidosis (10.7%), interstitial pneumonia (4.0%), pulmonary hypertension (8.9%) and bilateral lung transplantation for cystic fibrosis (36.0%). LFT measurements were described in 185 patients with NSP and indisputable nonoverlapping causes. A moderate defect (FEV1: 66 ± 9% predicted) with mild lung hyperinflation (FRC: 111 ± 27%, RV: 131 ± 33% predicted: suggesting distal airway obstruction) was evidenced whatever the underlying cause. A long term stability of NSP was evidenced in 130/185 patients (70% 95% CI: 64 to 77%).
conclusionsNSP is observed in asthma, COPD/emphysema, bronchiectasis, sarcoidosis, pulmonary hypertension, interstitial pneumonia and after bilateral lung transplantation and remains stable in the majority of patients.
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