ReviewCurrent opinion in virology2014
Sponging of cellular proteins by viral RNAs.
Review in Current opinion in virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Identification of old coding regions disproves the hominoid de novo status of genes.Nature ecology & evolution · 2024Article
- The 3' Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay.The Journal of infectious diseases · 2023Article
- Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs.Nucleic acids research · 2020Article
- Chasing Intracellular Zika Virus Using Proteomics.Viruses · 2019Review
- Subgenomic flavivirus RNA binds the mosquito DEAD/H-box helicase ME31B and determines Zika virus transmission byProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1.Cancers · 2019Article
- Identification of phlebovirus and arenavirus RNA sequences that stall and repress the exoribonuclease XRN1.The Journal of biological chemistry · 2018Article
- Review
- Noncoding RNAs of Plant Viruses and Viroids: Sponges of Host Translation and RNA Interference Machinery.Molecular plant-microbe interactions : MPMI · 2016Review
- Structured RNAs that evade or confound exonucleases: function follows form.Current opinion in structural biology · 2016Review
- Review
- Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Viral RNAs accumulate to high levels during infection and interact with a variety of cellular factors including miRNAs and RNA-binding proteins. Although many of these interactions exist to directly modulate replication, translation and decay of viral transcripts, evidence is emerging that abundant viral RNAs may in certain cases serve as a sponge to sequester host non-coding RNAs and proteins. By effectively reducing the ability of cellular RNA binding proteins to regulate host cell gene expression, viral RNAs can alter the response to infection and favor viral replication. This review focuses on the potential contribution that sequestration of cellular proteins by viral RNAs makes to viral replication and cytopathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.