SynthesisPsychoneuroendocrinology2014
Five-factor model personality traits and inflammatory markers: new data and a meta-analysis.
Synthesis in Psychoneuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Personality nuances and inflammation: A coordinated analysis of six samples.Psychoneuroendocrinology · 2026Pooled it
- Personality and mortality risk: A systematic review and meta-analysis of longitudinal data.Journal of personality and social psychology · 2026Pooled it
- Personality and Risk of Arthritis in Six Longitudinal Samples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Pooled it
- Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Personality associations with lung function and dyspnea: Evidence from six studies.Respiratory medicine · 2023Pooled it
- Five-factor model personality traits and grip strength: Meta-analysis of seven studies.Journal of psychosomatic research · 2022Pooled it
- Personality and fatigue: meta-analysis of seven prospective studies.Scientific reports · 2022Pooled it
- Personality moderates immunological and functional consequences of caregiver burden.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Personality and epigenetic aging: A multi-cohort and multi-clock study.Psychoneuroendocrinology · 2025Article
- Personality and falls: evidence from three samples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Serum TNF-Alpha and IL-10 Predict Reduced Sensitivity to Fear- and Anxiety-Related Traits in Healthy Older Dogs: Preliminary Evidence for Immune-Personality Signatures in Later Life.Animals : an open access journal from MDPI · 2025Article
- Are Higher-Order Constructs in Evolutionary Psychology Attributable to Omitted Cross-Loading Bias? An Exploratory Structural Equation Modeling Approach.Human nature (Hawthorne, N.Y.) · 2025Article
- Stress tests and biomarkers of resilience: Proceedings of the second state of resilience science conference.Journal of the American Geriatrics Society · 2025Article
- Personality and Psychoneuroimmunology: A Systems Biology Perspective.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Early adversity and inflammation at midlife: the moderating role of internalizing psychopathology.Psychological medicine · 2024Article
- The mediational role of hearing acuity in the association between personality and memory: Evidence from the health and retirement study and the English Longitudinal Study of Ageing.Journal of psychosomatic research · 2024Article
- Behavioral adjustment moderates the effect of neuroticism on brain volume relative to intracranial volume.Journal of personality · 2024Article
- Correlations between personality traits, personality disorders, and immunometabolic markers.Scientific reports · 2024Article
- Personality and Cognition: The Mediating Role of Inflammatory Markers.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Purpose in life and markers of immunity and inflammation: Testing pathways of episodic memory.Journal of psychosomatic research · 2023Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The purpose of this research is to examine the association between five major dimensions of personality and systemic inflammation through (a) new data on C-reactive protein (CRP) from three large national samples of adults that together cover most of the adult lifespan and (b) a meta-analysis of published studies on CRP and interleukin-6 (IL-6). New data (total N=26,305) were drawn from the National Longitudinal Study of Adolescent Health, the Midlife in the United States study, and the Health and Retirement Study. PRISMA guidelines were used for the meta-analysis to combine results of up to seven studies on CRP (N=34,067) and six on IL-6 (N=7538). Across the three new samples, higher conscientiousness was associated with lower CRP. The conscientiousness-CRP relation was virtually identical controlling for smoking; controlling for body mass index attenuated this association but did not eliminate it. Compared to participants in the highest quartile of conscientiousness, participants in the lowest quartile had an up to 50% increased risk of CRP levels that exceeded the clinical threshold (≥3 mg/l). The meta-analysis supported the association between conscientiousness and both CRP and IL-6 and also suggested a negative association between openness and CRP; no associations were found for neuroticism, extraversion and agreeableness. The present work indicates a modest, but consistent, association between conscientiousness and a more favorable inflammatory profile, which may contribute to the role of conscientiousness in better health across the lifespan.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.