ArticlePLoS pathogens2014
The effects of vaccination and immunity on bacterial infection dynamics in vivo.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
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- Control of Salmonella in poultry: The role of host immunity and vaccines.Poultry science · 2025Review
- Generation of Barcode-Tagged Vibrio fischeri Deletion Strains and Barcode Sequencing (BarSeq) for Multiplex Strain Competitions.Current protocols · 2024Article
- Early transcriptional responses to human enteric fever challenge.Infection and immunity · 2023Article
- Fitness advantage ofeLife · 2023Article
- USP8 inhibition regulates autophagy flux and controlsFrontiers in cellular and infection microbiology · 2023Article
- RESTAMP - Rate estimates by sequence-tag analysis of microbial populations.Computational and structural biotechnology journal · 2021Article
- An experimental design tool to optimize inference precision in data-driven mathematical models of bacterial infectionsJournal of the Royal Society, Interface · 2020Article
- Antibodies and Protection in SystemicInfection and immunity · 2020Review
- Impact of Vaccination and Pathogen Exposure Dosage on Shedding Kinetics of Infectious Hematopoietic Necrosis Virus (IHNV) in Rainbow Trout.Journal of aquatic animal health · 2020Article
- Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression.Mucosal immunology · 2020Article
- Integrating mathematical models with experimental data to investigate the within-host dynamics of bacterial infections.Pathogens and disease · 2019Review
- Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.Nature immunology · 2018Article
- Within-host spatiotemporal dynamics of systemic Salmonella infection during and after antimicrobial treatment.The Journal of antimicrobial chemotherapy · 2017Article
- An efficient moments-based inference method for within-host bacterial infection dynamics.PLoS computational biology · 2017Article
- Host Iron Nutritional Immunity Induced by a LiveFrontiers in cellular and infection microbiology · 2017Article
- Development of Antibiotic Resistance during Simulated Treatment of Pseudomonas aeruginosa in Chemostats.PloS one · 2016Article
- Article
- Single passage in mouse organs enhances the survival and spread of Salmonella enterica.Journal of the Royal Society, Interface · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Salmonella enterica infections are a significant global health issue, and development of vaccines against these bacteria requires an improved understanding of how vaccination affects the growth and spread of the bacteria within the host. We have combined in vivo tracking of molecularly tagged bacterial subpopulations with mathematical modelling to gain a novel insight into how different classes of vaccines and branches of the immune response protect against secondary Salmonella enterica infections of the mouse. We have found that a live Salmonella vaccine significantly reduced bacteraemia during a secondary challenge and restrained inter-organ spread of the bacteria in the systemic organs. Further, fitting mechanistic models to the data indicated that live vaccine immunisation enhanced both the bacterial killing in the very early stages of the infection and bacteriostatic control over the first day post-challenge. T-cell immunity induced by this vaccine is not necessary for the enhanced bacteriostasis but is required for subsequent bactericidal clearance of Salmonella in the blood and tissues. Conversely, a non-living vaccine while able to enhance initial blood clearance and killing of virulent secondary challenge bacteria, was unable to alter the subsequent bacterial growth rate in the systemic organs, did not prevent the resurgence of extensive bacteraemia and failed to control the spread of the bacteria in the body.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.