Evidence map›Paper›PMID 25232895›Full record

ArticleACS nano2014

Label-free optical detection of biomolecular translocation through nanopore arrays.

Andrey Ivankin, Robert Y Henley, Joseph Larkin, Spencer Carson, Michael L Toscano, Meni Wanunu

Abstract read
In one paragraph

Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
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  5. Metrology of Nanoscale Objects Using Nanopores.Methods in molecular biology (Clifton, N.J.) · 2026
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrey IvankinDepartment of Physics, Northeastern University , Boston, Massachusetts 02115, United States.
Robert Y Henley
Joseph Larkin
Spencer Carson
Michael L Toscano
Meni Wanunu

Funding

Optimization of Processive Enzymes for DNA Sequencing using NanoporesR01HG006321 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI AKESON, MARK A · 2011 to 2013
$3.6M
Picogram-level DNA sequencing using Nanopores and Zero-Mode WaveguidesR21HG006873 · NHGRI · NORTHEASTERN UNIVERSITY · PI KORLACH, JONAS, WANUNU, MENI · 2012 to 2014
$812k
NHGRI NIH HHS R01 HG006321NHGRI NIH HHS R01-HG006321NHGRI NIH HHS R21 HG006873NHGRI NIH HHS R21-HG006873
6 · The paper itself

Abstract

In recent years, nanopores have emerged as exceptionally promising single-molecule sensors due to their ability to detect biomolecules at subfemtomole levels in a label-free manner. Development of a high-throughput nanopore-based biosensor requires multiplexing of nanopore measurements. Electrical detection, however, poses a challenge, as each nanopore circuit must be electrically independent, which requires complex nanofluidics and embedded electrodes. Here, we present an optical method for simultaneous measurements of the ionic current across an array of solid-state nanopores, requiring no additional fabrication steps. Proof-of-principle experiments are conducted that show simultaneous optical detection and characterization of ssDNA and dsDNA using an array of pores. Through a comparison with electrical measurements, we show that optical measurements are capable of accessing equivalent transmembrane current information.

Indexed as

NanoporesOptics and PhotonicsBiological TransportMicroscopy, Electron, Transmissionfluorescenceionophorenanoporeoptical patch-clampingsingle-molecule

Identifiers

PMID25232895
PMCPMC4212781

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.