Evidence map›Paper›PMID 25232881›Full record

ReviewNeurosurgery2014

The new neurometabolic cascade of concussion.

Christopher C Giza, David A Hovda

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 560 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
560citing papers in PubMed, 9 pooled it
46.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03475693 early_phase1completednot on this mapstarted 2017, after this paper: background citation

A Cohort Study Evaluating the Efficacy of PO Magnesium in the Treatment of Acute Traumatic Brain Injury in Adolescents

TypeinterventionalSponsorCorewell Health SouthRan2017 to 2019Enrolled17ConditionsConcussion Post SyndromeArmsMagnesium Oxide, Acetaminophen, Zofran ODT 4 MG Disintegrating Oral Tablet
NCT06208813 narecruitingnot on this mapstarted 2024, after this paper: background citation

Assigned Creatine Ingestion With Usual Diet or Usual Diet Alone.

TypeinterventionalSponsorSan Diego State UniversityRan2024 to 2027Enrolled20ConditionsConcussion, BrainArmsCreatine
3 · Its place in the literature

Who cites it

560 citing papers in PubMed, 9 syntheses or guidelines pooled it, 1,294 citations in OpenAlex.

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500 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher C Giza*Division of Pediatric Neurology, Department of Pediatrics, Mattel Children's Hospital-UCLA, Los Angeles, California; ‡Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California; §Interdepartmental Programs for Neuroscience and Biomedical Engineering, UCLA, Los Angeles, California; ¶Department of Medical and Molecular Pharmacology, UCLA, Los Angeles, California.
David A Hovda
University of California, Los Angeles · US

Funding

The effects of glycemic control on post-traumatic brain metabolismP01NS058489 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 2009 to 2013
$6.2M
Using glutamatergic pharmacotherapy to optimize TBI recoveryR01NS027544 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 1990 to 2017
$3.8M
NINDS NIH HHS P01 NS058489NINDS NIH HHS R01 NS027544
6 · The paper itself

Abstract

Since the original descriptions of postconcussive pathophysiology, there has been a significant increase in interest and ongoing research to study the biological underpinnings of concussion. The initial ionic flux and glutamate release result in significant energy demands and a period of metabolic crisis for the injured brain. These physiological perturbations can now be linked to clinical characteristics of concussion, including migrainous symptoms, vulnerability to repeat injury, and cognitive impairment. Furthermore, advanced neuroimaging now allows a research window to monitor postconcussion pathophysiology in humans noninvasively. There is also increasing concern about the risk for chronic or even progressive neurobehavioral impairment after concussion/mild traumatic brain injury. Critical studies are underway to better link the acute pathobiology of concussion with potential mechanisms of chronic cell death, dysfunction, and neurodegeneration. This "new and improved" article summarizes in a translational fashion and updates what is known about the acute neurometabolic changes after concussive brain injury. Furthermore, new connections are proposed between this neurobiology and early clinical symptoms as well as to cellular processes that may underlie long-term impairment.

Indexed as

Athletic InjuriesBrain ConcussionFemaleHumansMaleNeuroimaging

Identifiers

PMID25232881
PMCPMC4479139
OpenAlexW2088800239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.