ArticlePLoS neglected tropical diseases2014
A new approach for monitoring ebolavirus in wild great apes.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Praemonitus praemunitus: can we forecast and prepare for future viral disease outbreaks?FEMS microbiology reviews · 2023Review
- Epidemiology of Ebolaviruses from an Etiological Perspective.Pathogens (Basel, Switzerland) · 2023Review
- Prevalence of antibodies against human respiratory viruses potentially involving anthropozoonoses in wild bonobos.Primates; journal of primatology · 2021Article
- The genetic impact of an Ebola outbreak on a wild gorilla population.BMC genomics · 2021Article
- Leptospirosis as a cause of fever associated with jaundice in the Democratic Republic of the Congo.PLoS neglected tropical diseases · 2021Article
- Article
- Article
- Long-term wildlife mortality surveillance in northern Congo: a model for the detection of Ebola virus disease epizootics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection.Frontiers in immunology · 2019Article
- Advancing Planetary Health in Australia: focus on emerging infections and antimicrobial resistance.BMJ global health · 2019Review
- Using physical contact heterogeneity and frequency to characterize dynamics of human exposure to nonhuman primate bodily fluids in central Africa.PLoS neglected tropical diseases · 2018Article
- Serologic Evidence of Ebolavirus Infection in a Population With No History of Outbreaks in the Democratic Republic of the Congo.The Journal of infectious diseases · 2018Article
- Detection of chronic wasting disease prion seeding activity in deer and elk feces by real-time quaking-induced conversion.The Journal of general virology · 2017Article
- Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Ebola virus disease.EFSA journal. European Food Safety Authority · 2017Article
- The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees?Scientific reports · 2017Article
- One Health proof of concept: Bringing a transdisciplinary approach to surveillance for zoonotic viruses at the human-wild animal interface.Preventive veterinary medicine · 2017Article
- Lessons from the Ebola Outbreak: Action Items for Emerging Infectious Disease Preparedness and Response.EcoHealth · 2016Review
- Article
- Whole genome capture of vector-borne pathogens from mixed DNA samples: a case study of Borrelia burgdorferi.BMC genomics · 2015Article
- Adenovirus and herpesvirus diversity in free-ranging great apes in the Sangha region of the Republic Of Congo.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundCentral Africa is a "hotspot" for emerging infectious diseases (EIDs) of global and local importance, and a current outbreak of ebolavirus is affecting multiple countries simultaneously. Ebolavirus is suspected to have caused recent declines in resident great apes. While ebolavirus vaccines have been proposed as an intervention to protect apes, their effectiveness would be improved if we could diagnostically confirm Ebola virus disease (EVD) as the cause of die-offs, establish ebolavirus geographical distribution, identify immunologically naïve populations, and determine whether apes survive virus exposure. METHODOLOGY/PRINCIPAL
findingsHere we report the first successful noninvasive detection of antibodies against Ebola virus (EBOV) from wild ape feces. Using this method, we have been able to identify gorillas with antibodies to EBOV with an overall prevalence rate reaching 10% on average, demonstrating that EBOV exposure or infection is not uniformly lethal in this species. Furthermore, evidence of antibodies was identified in gorillas thought previously to be unexposed to EBOV (protected from exposure by rivers as topological barriers of transmission). CONCLUSIONS/SIGNIFICANCE: Our new approach will contribute to a strategy to protect apes from future EBOV infections by early detection of increased incidence of exposure, by identifying immunologically naïve at-risk populations as potential targets for vaccination, and by providing a means to track vaccine efficacy if such intervention is deemed appropriate. Finally, since human EVD is linked to contact with infected wildlife carcasses, efforts aimed at identifying great ape outbreaks could have a profound impact on public health in local communities, where EBOV causes case-fatality rates of up to 88%.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.