ArticlePLoS computational biology2014
Multidimensional epistasis and the transitory advantage of sex.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- STUN: forward-time simulation on TUnable fitNess landscapes in recombining populations.Bioinformatics advances · 2023Article
- Conflicting effects of recombination on the evolvability and robustness in neutrally evolving populations.PLoS computational biology · 2022Review
- Recombination and mutational robustness in neutral fitness landscapes.PLoS computational biology · 2019Article
- Recombination and peak jumping.PloS one · 2018Article
- Evolution at 'Sutures' and 'Centers': Recombination Can Aid Adaptation of Spatially Structured Populations on Rugged Fitness Landscapes.PLoS computational biology · 2016Article
- Sex in a test tube: testing the benefits of in vitro recombination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- An Evolving Genetic Architecture Interacts with Hill-Robertson Interference to Determine the Benefit of Sex.Genetics · 2016Article
- Fitness Trade-Offs in Competence Differentiation of Bacillus subtilis.Frontiers in microbiology · 2016Article
- ComGA-RelA interaction and persistence in the Bacillus subtilis K-state.Molecular microbiology · 2015Article
- Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying and quantifying the benefits of sex and recombination is a long-standing problem in evolutionary theory. In particular, contradictory claims have been made about the existence of a benefit of recombination on high dimensional fitness landscapes in the presence of sign epistasis. Here we present a comparative numerical study of sexual and asexual evolutionary dynamics of haploids on tunably rugged model landscapes under strong selection, paying special attention to the temporal development of the evolutionary advantage of recombination and the link between population diversity and the rate of adaptation. We show that the adaptive advantage of recombination on static rugged landscapes is strictly transitory. At early times, an advantage of recombination arises through the possibility to combine individually occurring beneficial mutations, but this effect is reversed at longer times by the much more efficient trapping of recombining populations at local fitness peaks. These findings are explained by means of well-established results for a setup with only two loci. In accordance with the Red Queen hypothesis the transitory advantage can be prolonged indefinitely in fluctuating environments, and it is maximal when the environment fluctuates on the same time scale on which trapping at local optima typically occurs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.