Evidence map›Paper›PMID 25232509›Full record

ArticleSouthwest journal of pulmonary & critical care2014

Lack of Impact of Mild Obstructive Sleep Apnea on Sleepiness, Mood and Quality of Life.

Stuart F Quan, Rohit Budhiraja, Salma Batool-Anwar, Daniel J Gottlieb, Phillip Eichling, Sanjay Patel, Wei Shen, James K Walsh, Clete A Kushida

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Southwest journal of pulmonary & critical care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00051363 (APPLES), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00051363 phase3completednot on this map

APPLES: Apnea Positive Pressure Long-Term Efficacy Study

TypeinterventionalSponsorStanford UniversityRan2002 to 2008Enrolled1,105ConditionsLung Diseases, Sleep Apnea Syndromes, SleepArmsActive CPAP, Sham CPAP
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. The effectiveness of sleep breathing impairment index in assessing obstructive sleep apnea severity.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  8. Exercise as a treatment for sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
  9. Why do we sometimes ignore the chief complaint in patients evaluated for obstructive sleep apnea?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
  10. Article
  11. Article
  12. The correlation between growth hormone receptor (GHR) polymorphism and obstructive sleep apnea syndrome among the Han and Hani population in China.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Clinical Prediction Models for Sleep Apnea: The Importance of Medical History over Symptoms.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Stuart F QuanDivision of Sleep Medicine, Harvard Medical School, Boston, MA ; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA ; Arizona Respiratory Center, University of Arizona, Tucson, AZ.
Rohit BudhirajaDepartment of Medicine, Tufts University School of Medicine, Boston, MA.
Salma Batool-AnwarDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA.
Daniel J GottliebDivision of Sleep Medicine, Harvard Medical School, Boston, MA ; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA ; VA Boston Healthcare System, Boston, MA.
Phillip EichlingCollege of Medicine, University of Arizona, Tucson, AZ ; Comprehensive Sleep Solutions, Tucson, AZ.
Sanjay PatelDivision of Sleep Medicine, Harvard Medical School, Boston, MA ; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA.
Wei ShenArizona Respiratory Center, University of Arizona, Tucson, AZ ; Southern Arizona VA Health Care System, Tucson, AZ.
James K WalshSleep Medicine and Research Center, St. Luke's Hospital, Chesterfield, MO.
Clete A KushidaStanford University Sleep Clinic and Center for Human Sleep Research, Redwood City, CA.
Brigham and Women's Hospital · USStanford University · USSt. Luke's Hospital · USTufts University · US

Funding

APPLES: Apnea Positive Pressure Long-Term Efficacy StudyU01HL068060 · NHLBI · STANFORD UNIVERSITY · PI KUSHIDA, CLETE A · 2002 to 2007
$14.1M
NHLBI NIH HHS U01 HL068060
6 · The paper itself

Abstract

BACKGROUND AND

objectivesObstructive sleep apnea (OSA) is associated with sleepiness, depression and reduced quality of life. However, it is unclear whether mild OSA has these negative impacts. Using data from the Apnea Positive Pressure Long-term Efficacy Study (APPLES), this study determined whether participants with mild OSA had greater sleepiness, more depressive symptoms and poorer quality of life in comparison to those without OSA.

methods239 individuals evaluated for participation in APPLES with a baseline apnea hypopnea index (AHI) < 15 /hour were assigned to 1 of 2 groups: No OSA (N=40, AHI < 5 /hour) or Mild OSA (N=199, 5 to <15 /hour) based on their screening polysomnogram. Scores on their Epworth Sleepiness Scale (ESS), Stanford Sleepiness Scale (SSS), Hamilton Rating Scale for Depression (HAM-D), Profile of Mood States (POMS) and Sleep Apnea Quality of Life Index (SAQLI) were compared between groups.

resultsThere were no significant differences between the No OSA and Mild OSA groups on any of the 5 measures: ESS (No OSA, 9.8 ± 3.5 vs Mild OSA, 10.6 ± 4.3, p=0.26), SSS,(2.8 ± 0.9 vs. 2.9 ± 1.0, p=0.52), HAM-D (4.6 ± 3.0 vs. 4.9 ± 4.7, p=0.27), POMS (33.5 ± 22.3 vs. 28.7 ± 22.0, p=0.70), SAQLI (4.5 ± 0.8 vs. 4.7 ± 0.7, p=0.39).

conclusionIndividuals with mild OSA in this cohort do not have worse sleepiness, mood or quality of life in comparison to those without OSA.

Identifiers

PMID25232509
PMCPMC4163952
OpenAlexW2133975367

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.