Evidence map›Paper›PMID 25232454›Full record

ArticleWorld journal of hepatology2014

Circulating microRNAs in patients with non-alcoholic fatty liver disease.

Mehmet Celikbilek, Mevlut Baskol, Serpil Taheri, Kemal Deniz, Serkan Dogan, Gokmen Zararsiz, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Munis Dundar and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 5 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Oligonucleotide therapies for nonalcoholic steatohepatitis.Molecular therapy. Nucleic acids · 2024
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mehmet CelikbilekMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Mevlut BaskolMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Serpil TaheriMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Kemal DenizMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Serkan DoganMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Gokmen ZararsizMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Sebnem GursoyMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Kadri GuvenMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Omer OzbakırMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Munis DundarMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Mehmet YucesoyMehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
Erciyes University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify novel non-invasive biomarkers for non-alcoholic fatty liver disease (NAFLD).

methodsTwenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The relative expressions of miR-197, miR-146b, miR-10b, miR-181d, miR-34a, miR-122, miR-99a and miR-29a were analyzed using real-time polymerase chain reaction.

resultsSerum levels of miR-181d, miR-99a, miR-197 and miR-146b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum levels of miR-197 and miR-10b were inversely correlated with degree of inflammation and miR-181d and miR-99a were inversely correlated with serum gamma glutamyl transferase levels in non-alcoholic steatohepatitis patients.

conclusionNAFLD is associated with altered serum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD.

Indexed as

MicroRNANonalcoholic fatty liver diseaseNonalcoholic steatohepatitisNoninvasiveSerum markers

Identifiers

PMID25232454
PMCPMC4163744
OpenAlexW1544572219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.