ReviewWorld journal of hepatology2014
Vertical hepatitis C virus transmission: Main questions and answers.
Review in World journal of hepatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Pregnancy outcome following hematopoietic cell transplantation for thalassemia major.Bone marrow transplantation · 2017Trial
- Direct-Acting Antiviral Agents in Prevention of Maternal-Fetal Transmission of Hepatitis C Virus in Pregnancy.Pathogens (Basel, Switzerland) · 2024Review
- Placental deficiency during maternal SARS-CoV-2 infection.Placenta · 2022Article
- Placental Immune Responses to Viruses: Molecular and Histo-Pathologic Perspectives.International journal of molecular sciences · 2021Review
- SARS-CoV-2 Infection in Pregnant Women: Neuroimmune-Endocrine Changes at the Maternal-Fetal Interface.Neuroimmunomodulation · 2021Review
- Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2s.Prenatal diagnosis · 2020Review
- Perinatal transmission of hepatitis C virus: an update.Archives of medical science : AMS · 2020Article
- Review article: direct-acting antivirals for the treatment of HCV during pregnancy and lactation - implications for maternal dosing, foetal exposure, and safety for mother and child.Alimentary pharmacology & therapeutics · 2019Review
- Seroprevalence of hepatitis B, hepatitis C, and HIV in pregnant women from Eastern Turkey.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Sexually acquired acute hepatitis C infection diagnosed during pregnancy: a case report of successful postpartum treatment.Case reports in women's health · 2018Article
- Current evidence on the management of hepatitis B in pregnancy.World journal of hepatology · 2018Review
- Hepatitis C virus infection in children: How do we prevent it and how do we treat it?Expert review of anti-infective therapy · 2018Review
- Prevalence of Hepatitis C Virus and HIV Infection Among Pregnant Women Attending Antenatal Care Clinic in Western Ethiopia.Frontiers in medicine · 2018Article
- Mechanisms and Prevention of Vertical Transmission in Chronic Viral Hepatitis.Journal of clinical and translational hepatology · 2017Review
- Ongoing Transmission of HCV: Should Cesarean Section be Justified? Data Mining Discovery.Journal of translational internal medicine · 2017Article
- Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women?World journal of hepatology · 2016Review
- Observational
- Single Clinical Practice's Report of Testing Initiation, Antibody Clearance, and Transmission of Hepatitis C Virus (HCV) in Infants of Chronically HCV-Infected Mothers.Open forum infectious diseases · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) affects about 3% of the world's population and peaks in subjects aged over 40 years. Its prevalence in pregnant women is low (1%-2%) in most western countries but drastically increases in women in developing countries or with high risk behaviors for blood-transmitted infections. Here we review clinical, prognostic and therapeutic aspects of HCV infection in pregnant women and their offspring infected through vertical transmission. Pregnancy-related immune weakness does not seem to affect the course of acute hepatitis C but can affect the progression of chronic hepatitis C. In fact, postpartum immune restoration can exacerbate hepatic inflammation, thereby worsening the liver disease, particularly in patients with liver cirrhosis. HCV infection increases the risk of gestational diabetes in patients with excessive weight gain, premature rupture of membrane and caesarean delivery. Only 3%-5% of infants born to HCV-positive mothers have been infected by intrauterine or perinatal transmission. Maternal viral load, human immunodeficiency virus coinfection, prolonged rupture of membranes, fetal exposure to maternal infected blood consequent to vaginal or perineal lacerations and invasive monitoring of fetus increase the risk of viral transmission. Cesarean delivery and breastfeeding increases the transmission risk in HCV/human immunodeficiency virus coinfected women. The consensus is not to offer antiviral therapy to HCV-infected pregnant women because it is based on ribavirin (pregnancy category X) because of its embryocidal and teratogenic effects in animal species. In vertically infected children, chronic C hepatitis is often associated with minimal or mild liver disease and progression to liver cirrhosis and hepatocarcinoma is lower than in adults. Infected children may be treated after the second year of life, given the adverse effects of current antiviral agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.