ArticleInternational journal of clinical and experimental medicine2014
Relationship of high CH50 level and interruption of cascade reaction of complement mRNA expression in acute venous thromboembolism patients.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Exploring the inflammatory origins of gouty arthritis: mechanistic studies based on local lesion proteomics and validation.Frontiers in immunology · 2026Article
- Reduced hemolytic complement activity in the classical pathway (CH50) is a risk factor for poor clinical outcomes of patients with infections: a retrospective analysis of health insurance claims in Japan.Frontiers in immunology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
In patients with pulmonary embolism (PE), forepart components of complements were activated. However there are interruption/decrease of cascade reaction and cytolytic effects in complement system. This study detected CRP, CH50, C3 and C4 levels in patients with venous thromboembolism (VTE) and compare with the imbalance of complement associated gene mRNA expression in PE patients. There was significant increase of CH50 in acute VTE patients. Even though CH50 increased significantly in acute VTE patients and had a relatively high sensitivity, cytolytic effects of complements might decrease, based on the genomics results of complement cascade reactions imbalance/interruption and increased total complements in VTE patients.
Indexed as
Identifiers
25232435PMC4161595What OpenQuestion holds
Registered trials
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