ArticleInternational journal of clinical and experimental medicine2014
Th1/Th2 cytokine pattern in Arab children with severe asthma.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Gut Microbiota Modulation in Asthma-An In Vitro Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Clinical characteristics and risk factors forFrontiers in pediatrics · 2024Article
- Regulation of γδT17 cells by Mycobacterium vaccae through interference with Notch/Jagged1 signaling pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Changes in the Th9 cell population and related cytokines in the peripheral blood of infants with recurrent wheezing.Central-European journal of immunology · 2020Article
- Anti-Asthma Effect of an Active Components Group from Decoction ofIranian journal of pharmaceutical research : IJPR · 2019Article
- Fructo-Oligosaccharide Alleviates Soybean-Induced Anaphylaxis in Piglets by Modulating Gut Microbes.Frontiers in microbiology · 2018Article
- Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan.Scientific reports · 2017Article
- Effects of salbutamol aerosol combined with magnesium sulfate on T-lymphocyte subgroup and Th1/Th2 cytokines of pediatric asthma.Experimental and therapeutic medicine · 2017Article
- Relationships between Th1/Th2 cytokine profiles and chest radiographic manifestations in childhoodTherapeutics and clinical risk management · 2016Article
- Upregulation of Tim-3 on CD4(+) T cells is associated with Th1/Th2 imbalance in patients with allergic asthma.International journal of clinical and experimental medicine · 2015Article
- Identification of Asthma Subtypes Using Clustering Methodologies.Pulmonary therapyReview
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBronchial Asthma has recently emerged as one of the most prevalent diseases in Arab countries. Environmental and geographical influences were shown to be the reasons of the variations in the rates of prevalence; no analyses have nevertheless yet been performed on the immunologic background associated with this condition in Arabic children.
objectivesTo examine the cytokine production from T cells in children with and without asthma, and to determine the role of the most related cytokine patterns in childhood asthma.
methodsA total of 195 Saudis children (98 asthma pediatric patients and 97 healthy controls) were randomly selected from the Riyadh Cohort Study for inclusion. Asthma was based on established pediatric diagnosis and medications taken.
resultsSignificant differences were observed between the two groups, thus, GMCSF, INF-γ, IL-5, IL-6, IL-8 and IgG-3 were reduced in patients compared to controls; in these same patients IgE, resistin, IL-4 and IgG-4 were significantly increased. In contrast with these results no differences between patients and controls were seen in CRP, TNF-α, IL-1, IL-2, IL-7, IL-10, IL-13, IgG-1, IgG-2, IgG-A and IgG-M. Result of a principal component analysis suggested that IL4. INF-γ and IgE are major players in the pathogenesis of asthma in Arabic children.
conclusionThese are the first data obtained in asthmatic children in Saudi; data herein confirm that this disease is associated with a profound degree of immune impairment independently of the peculiar genetic of the analyzed individuals, and of the environmental conditions that are present in this part of the world.
Indexed as
Identifiers
25232422PMC4161582W82820947What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.