ArticleInternational journal of clinical and experimental medicine2014
IL-1RA +2018 polymorphism and the susceptivity to pneumoconiosis: a Meta-analysis.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Cytokine Profiles as Predictive Biomarkers of Disease Severity and Progression in Engineered Stone Silicosis: A Machine Learning Approach.Diagnostics (Basel, Switzerland) · 2025Article
- A polymorphism in the FAM13A gene confers protection against tuberculosis in Brazilian workers exposed to silica.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Article
- Biomonitoring Exposure and Early Diagnosis in Silicosis: A Comprehensive Review of the Current Literature.Biomedicines · 2022Review
- Genetic polymorphisms and their effects on the severity of silicosis in workers exposed to silica in Brazil.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022Article
- Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIt has been reported that host genetic factors may play a crucial role in pneumoconiosis susceptibility. The present study aimed to study the association between IL-1RA +2018 polymorphism and pneumoconiosis by Meta-analysis. MATERIALS AND
methodsLiteratures addressing the association between IL-1RA gene polymorphisms and pneumoconiosis were selected from the PubMed, Cochrane Library, EMBASE, CNKI and Wanfang databases. Statistical analyses were performed by Review Manager Software 5.0.24 and STATA 11.0 software.
results5 case-control studies with a total of 609 pneumoconiosis patients and 579 controls were retrieved. Meta-analysis results showed significant association between IL-1RA +2018 polymorphism and pneumoconiosis risk. The C allele carriers have increased risk compared with the T allele carriers (OR=1.68, 95% CI: 1.25-2.27, P=0.0007). Individuals who carry TC or CC genotype have higher risk than those with TT homozygote (OR=1.79, 95% CI: 1.18, 2.71, P=0.006). In subgroup analysis by pneumoconiosis type, a significant association between IL-1RA +2018 polymorphism and pneumoconiosis risk were found in silicosis (C vs T: OR=2.12, 95% CI: 1.63-2.76, P=0.000; TC+CC vs TT: OR=1.79, 95% CI: 1.18-2.71, P=0.006) but not in coal workers' pneumoconiosis.
conclusionThis Meta-analysis suggests that IL-1RA +2018 polymorphism might be risk factors for pneumoconiosis, especially in silicosis.
Indexed as
Identifiers
25232408PMC4161568W2177905164What OpenQuestion holds
Registered trials
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