ArticleInternational journal of clinical and experimental medicine2014
Changes in reactive oxygen species, superoxide dismutase, and hypoxia-inducible factor-1α levels in missed abortion.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Correlation of changes in circulating levels of hypoxia-induced factor-1α, erythropoietin, and cell-free fetal hemoglobin with feto-maternal pregnancy outcomes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- The Impact of Early Pregnancy and Exposure to Tobacco Smoke on Blood Antioxidant Status and Copper, Zinc, Cadmium Concentration-A Pilot Study.Antioxidants (Basel, Switzerland) · 2021Article
- HIF-1α-Deficiency in Myeloid Cells Leads to a Disturbed Accumulation of Myeloid Derived Suppressor Cells (MDSC) During Pregnancy and to an Increased Abortion Rate in Mice.Frontiers in immunology · 2019Article
- Early missed abortion is associated with villous angiogenesis via the HIF-1α/VEGF signaling pathway.Archives of gynecology and obstetrics · 2018Article
- MicroRNA expression profiling in placenta and maternal plasma in early pregnancy loss.Molecular medicine reports · 2018Article
- Abnormal expression of microRNA-575 leads to missed abortion through regulating apoptosis and angiogenesis.Experimental and therapeutic medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate changes in the expression levels of reactive oxygen species (ROS), superoxide dismutase (SOD), and hypoxia-inducible factor-1α (HIF-1α) in the trophoblasts of patients who had experienced missed abortions. The missed abortion group included 28 patients with missed abortions. The control group was comprised of 35 women who had elected to undergo surgically induced abortion in their first trimester, and whose embryos were confirmed to be alive before surgery. No woman in either group had any known causative factor for missed or spontaneous abortion. As soon as the diagnosis of "missed abortion" was definitively made, the chorionic trophoblast was obtained by induced abortion operation. The same method was used for individuals in the control group, who were at 7-10 weeks of pregnancy. Levels of ROS, SOD, and HIF-1α in the chorionic trophoblasts from women in both groups were examined within 1 hour by fluorescent staining, chemiluminometry, and enzyme immunoassay methods. The SOD and HIF-1α levels were lower and the ROS level was higher in the trophoblasts from women in the missed abortion group compared to levels in the control group (P < 0.05). ROS, SOD and HIF-1α levels in the chorionic trophoblasts from patients with missed abortion are altered compared to levels in control patients. Changes in these factors should be evaluated further for their potential role in missed abortion.
Indexed as
Identifiers
25232404PMC4161564W256172399What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.