ArticleInternational journal of clinical and experimental medicine2014
miR-148b functions as a tumor suppressor in non-small cell lung cancer by targeting carcinoembryonic antigen (CEA).
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Identification of potential core genes and miRNAs in pediatric ACCIntractable & rare diseases research · 2022Article
- MiR-148b-3p Regulates the Expression of DTYMK to Drive Hepatocellular Carcinoma Cell Proliferation and Metastasis.Frontiers in oncology · 2021Article
- [Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020Article
- MicroRNA-148b enhances the radiosensitivity of B-cell lymphoma cells by targeting Bcl-w to promote apoptosis.International journal of biological sciences · 2020Article
- Efficacy of Huaier granule in patients with breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
- MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway.BMC cancer · 2019Article
- 3D carbon nanosphere and gold nanoparticle-based voltammetric cytosensor for cell line A549 and for early diagnosis of non-small cell lung cancer cells.Mikrochimica acta · 2018Article
- miR-148b-3p functions as a tumor suppressor in GISTs by directly targeting KIT.Cell communication and signaling : CCS · 2018Article
- H19 knockdown suppresses proliferation and induces apoptosis by regulating miR-148b/WNT/β-catenin in ox-LDL -stimulated vascular smooth muscle cells.Journal of biomedical science · 2018Article
- Evaluating the prognostic value of miR-148/152 family in cancers: based on a systemic review of observational studies.Oncotarget · 2017Article
- A nanobody targeting carcinoembryonic antigen as a promising molecular probe for non-small cell lung cancer.Molecular medicine reports · 2017Article
- MicroRNA-148b suppresses proliferation, migration, and invasion of nasopharyngeal carcinoma cells by targeting metastasis-associated gene 2.OncoTargets and therapy · 2017Article
- Chemopreventive Potential of 2,3,5,4'-Tetrahydroxystilbene-2-O-BioMed research international · 2017Article
- Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- miRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homologue 1.Bioscience reports · 2016Article
- Downregulation of miR-148b as biomarker for early detection of hepatocellular carcinoma and may serve as a prognostic marker.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Comparison of Serum MicroRNA21 and Tumor Markers in Diagnosis of Early Non-Small Cell Lung Cancer.Disease markers · 2016Article
- MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9.Molecular medicine reports · 2016Article
- Down-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients.Diagnostic pathology · 2015Article
- miRNA-148b suppresses hepatic cancer stem cell by targeting neuropilin-1.Bioscience reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant expression of miR-148b has been found in several types of cancer, but its expression and potential biologic role in non-small cell lung cancer (NSCLC) are still largely unknown. Here, we found that miR-148b was commonly under-expressed in human non-small celllung cancer (NSCLC) specimens and cell lines. The overexpression of miR-148b dramatically suppressed NSCLC cell proliferation and migration. Furthermore, miR-148b could regulate carcinoembryonic antigen (CEA) expression by luciferase reporter assay. On the other hand, CEA was widely up-regulated in NSCLC specimens, and its mRNA levels were inversely correlated with miR-148b expression. These suggest that CEA expression may be regulated by miR-148b. Collectively, our findings indicate miR-148b is low expression in NSCLC cells, which results in CEA overexpression and disease progression in NSCLC patients.
Indexed as
Identifiers
25232379PMC4161539W2260269675What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.