Evidence map›Paper›PMID 25232355›Full record

ReviewFrontiers in immunology2014

Ontogeny of myeloid cells.

Ismé De Kleer, Fabienne Willems, Bart Lambrecht, Stanislas Goriely

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review.International journal of molecular sciences · 2020
    Pooled it
  2. Article
  3. The Role of Glucose Metabolism inInternational journal of molecular sciences · 2026
    Article
  4. Review
  5. Article
  6. Developmental Pathways of Immature CD11cInternational journal of molecular sciences · 2026
    Review
  7. Review
  8. Neonatal CD19Frontiers in immunology · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. The Roles of Myeloid Cells in Breast Cancer Progression.Advances in experimental medicine and biology · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ismé De KleerVIB Inflammation Research Center, University of Ghent , Ghent , Belgium ; Department of Respiratory Medicine, University Hospital Ghent , Ghent , Belgium ; Department of Pulmonary Medicine, Erasmus MC , Rotterdam , Netherlands.
Fabienne WillemsInstitute for Medical Immunology (IMI), Université Libre de Bruxelles , Charleroi , Belgium.
Bart LambrechtVIB Inflammation Research Center, University of Ghent , Ghent , Belgium ; Department of Respiratory Medicine, University Hospital Ghent , Ghent , Belgium.
Stanislas GorielyInstitute for Medical Immunology (IMI), Université Libre de Bruxelles , Charleroi , Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Granulocytes, monocytes, macrophages, and dendritic cells (DCs) represent a subgroup of leukocytes, collectively called myeloid cells. During the embryonic development of mammalians, myelopoiesis occurs in a stepwise fashion that begins in the yolk sac and ends up in the bone marrow (BM). During this process, these early monocyte progenitors colonize various organs such as the brain, liver, skin, and lungs and differentiate into resident macrophages that will self-maintain throughout life. DCs are constantly replenished from BM precursors but can also arise from monocytes in inflammatory conditions. In this review, we summarize the different types of myeloid cells and discuss new insights into their early origin and development in mice and humans from fetal to adult life. We specifically focus on the function of monocytes, macrophages, and DCs at these different developmental stages and on the intrinsic and environmental influences that may drive these adaptations.

Indexed as

cytokinedendritic cellfetusmacrophagemicrobiotamonocyteneonateTLR

Identifiers

PMID25232355
PMCPMC4153297

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.