ReviewPerspectives in medicinal chemistry2014
Antibiotics and bacterial resistance in the 21st century.
Review in Perspectives in medicinal chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 689 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
689 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Appendectomy versus antibiotic treatment for acute appendicitis.The Cochrane database of systematic reviews · 2024Pooled it
- Prevalence of Antibiotic Resistance in Older Adults and Alzheimer's Disease Patients: A Systematic Review and Meta-Analysis.Journal of Alzheimer's disease reports · 2024Pooled it
- Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000-2025).Medicinal research reviews · 2026Review
- Biomedical Properties, Developments and Therapeutic Potential of Sesquiterpenoid Lactones and Natural Compounds.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Divergent stakeholder perspectives on antimicrobial resistance and One Health in Ghana: a qualitative study.BMC global and public health · 2026Article
- Investigating a Medicinally Important Novel Species of Termitomyces From the Lateritic Region of West Bengal.Biotechnology and applied biochemistry · 2026Article
- Beyond the Standard Antibiogram: Unveiling the Roles of pH and Salinity in Modulating Gentamicin Efficacy Against Escherichia coli in Urinary Tract Infections.MicrobiologyOpen · 2026Article
- Giving Antibiotics a Second Chance: Evolutionary Trade-Offs and Phage-Driven Restoration of Antibiotic Susceptibility.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Multiplexing antibiotic screening assay in droplet microfluidics.Scientific reports · 2026Article
- A Pilot Study on the Prevalence and Characterization of Multidrug-Resistant Gram-Negative Bacteria in Chicken and Pork Meat Around Kathmandu District, Nepal.MicrobiologyOpen · 2026Article
- Ethanolic extracts from deep marine sponges: A new frontier in antibacterial discovery from the Jordanian Gulf of Aqaba.Biomedical reports · 2026Article
- Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655.BMC microbiology · 2026Article
- Molecular Docking and Structure-Activity Relationship Study of Polyphenols with Antibacterial and Antibiotic-Modulating Properties.Microorganisms · 2026Article
- A novel synergistic action of phage vB_PaeP_GZMU_A1002 with allicin against carbapenem-resistant Pseudomonas aeruginosa.Biology direct · 2026Article
- Prevalence and antibiogram of Staphylococcus aureus isolates in bovine raw milk from small-scale farmers in Magu district, Mwanza, Tanzania.BMC veterinary research · 2026Article
- Microfluidic point-of-care testing for antimicrobial resistance: advances, strategies, and One Health perspectives.Science in One Health · 2026Review
- Antimicrobial Resistance, Virulence, and Genomic Characteristics ofTransboundary and emerging diseases · 2026Article
- Antibacterial and antioxidant potentials of larval extract of black soldier fly,Biotechnologia · 2026Article
- Molecular resistome profiling of multidrug-resistantBioinformation · 2026Article
629 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over the past several decades. In this review the factors that have been linked to this phenomenon are addressed. Profiles of bacterial species that are deemed to be particularly concerning at the present time are illustrated. Factors including economic impact, intrinsic and acquired drug resistance, morbidity and mortality rates, and means of infection are taken into account. Synchronously with the waxing of bacterial resistance there has been waning antibiotic development. The approaches that scientists are employing in the pursuit of new antibacterial agents are briefly described. The standings of established antibiotic classes as well as potentially emerging classes are assessed with an emphasis on molecules that have been clinically approved or are in advanced stages of development. Historical perspectives, mechanisms of action and resistance, spectrum of activity, and preeminent members of each class are discussed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.