Evidence map›Paper›PMID 25232260›Full record

Observational studyWorld journal of gastroenterology2014

Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis.

Philipp Lenz, Franziska Eckelskemper, Thomas Erichsen, Tim Lankisch, Alexander Dechêne, Gabriele Lubritz, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt and 1 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01109550 (Biliary Candidiasis - Evaluation of Risk Factors, Implementation of an Algorithm in Diagnostics and Therapy), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01109550 completednot on this map

Biliary Candidiasis - Evaluation of Risk Factors, Implementation of an Algorithm in Diagnostics and Therapy

TypeobservationalSponsorUniversity Hospital MuensterRan2011 to 2013Enrolled123ConditionsSecondary Cholangitis, Bile Duct Strictures of Unknown OriginArmsERCP
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Outcomes Following Antifungal Treatment forJournal of fungi (Basel, Switzerland) · 2026
    Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Intra-abdominalJournal of clinical pathology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Philipp LenzPhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Franziska EckelskemperPhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Thomas ErichsenPhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Tim LankischPhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Alexander DechênePhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Gabriele LubritzPhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Frank LenzePhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Torsten BeynaPhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Hansjörg UllerichPhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Andre SchmedtPhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Dirk DomagkPhilipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, Germany.
Daimler (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis.

methodsWe performed a prospective study of 127 patients who underwent endoscopic retrograde cholangiopancreatography, for various biliary disorders, at 3 tertiary referral centers in Germany from July 2011 through July 2012 (ClinicalTrials.gov: NCT01109550). Bile, buccal, and stool samples were collected. When indicated, endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal infections.

resultsCandida species were detected in 38 of the 127 bile samples (29.9%). By multivariate analysis patients' age and previous endoscopic sphincterotomy were independent risk factors for biliary candidiasis (P < 0.05). Patients with immunosuppression (P = 0.058) and recent long-term antibiotic therapy (> 7 d) (P = 0.089) tend to be at risk for biliary candidiasis. One patient was negative in mycological culture of bile fluid but invasive biliary candidiasis was diagnosed histologically. Of Candida subspecies detected, 36.7% were azole-resistant, such as C glabrata. Eight patients received anti-mycotic therapy, based on our algorithm. Of these, 3 had cancer with biliary tract involvement, 2 had secondary sclerosing cholangitis, 1 had retroperitoneal fibrosis, and 5 had septicemia. In all patients contamination was ruled out by smears of the endoscope channel.

conclusionGastroenterologists should be aware of frequent candida colonization in patients with cholangitis and biliary disorders. Our suggested algorithm facilitates the further clinical management.

Indexed as

AlgorithmsAdultAgedAntifungal AgentsBacteriological TechniquesBileBiopsyCandidaCandidiasisChi-Square DistributionCholangiopancreatography, Endoscopic RetrogradeCholangitisCholestasisConstriction, PathologicCritical PathwaysFecesAntifungal AgentsBiliary candidiasisBiliary obstructionCholangitisInvasive fungal infection

Identifiers

PMID25232260
PMCPMC4161811
OpenAlexW1981057885

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.