Observational studyWorld journal of gastroenterology2014
Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis.
Observational study in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Epigenetic Landscapes in Ulcerative Colitis: From Mechanistic Insights to Clinical Translation.ACS omega · 2025Review
- Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research.United European gastroenterology journal · 2025Review
- Integrative analysis of single-cell and microarray data reveals SPI1-centered macrophage regulatory signatures in ulcerative colitis.Frontiers in genetics · 2025Article
- Article
- Mucosal Interleukin-10 depletion in steroid-refractory Crohn's disease patients.Immunity, inflammation and disease · 2022Article
- Microscopic colitis: an update.Medicine and pharmacy reports · 2022Review
- Pooled CRISPR screening identifies mScience advances · 2021Article
- Controversials of Microscopic Colitis.Frontiers in medicine · 2021Review
- Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta analysis.Medicine · 2020Article
- Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer's Disease Based on Systems Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Cancer Risk in Collagenous Colitis.Journal of clinical medicine · 2019Article
- Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation.Frontiers in immunology · 2019Review
- Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs.Scientific reports · 2018Article
- Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy.Oncology letters · 2018Article
- Interleukin-37: A Peacekeeper at the Intestinal Borders.Digestive diseases and sciences · 2017Article
- Reduced IL-37 Production Increases Spontaneous Chemokine Expressions in Colon Epithelial Cells.Digestive diseases and sciences · 2017Article
- Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M.EBioMedicine · 2017Article
- Increased duodenal expression of miR-146a and -155 in pediatric Crohn's disease.World journal of gastroenterology · 2016Article
- Suppression of innate inflammation and immunity by interleukin-37.European journal of immunology · 2016Review
- Diagnosis and management of microscopic colitis: current perspectives.Clinical and experimental gastroenterology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate Toll-like receptor (TLR) signaling regulators in microscopic and ulcerative colitis patients.
methodsTotal RNA and microRNA were isolated from fresh frozen colonic biopsies of non-inflamed controls and patients with active or in-remission collagenous colitis (CC), lymphocytic colitis (LC), or ulcerative colitis (UC). We compared expressions of interleukin-1 receptor-associated kinase (IRAK)-2, IRAK-M, interleukin (IL)-37, microRNA (miR)-146a, miR-155, and miR-21 using quantitative real time reverse transcription polymerase chain reaction.
resultsIRAK-M expression was increased in LC patients with active disease in histopathological remission (LC-HR; P = 0.02) and UC patients (P = 0.01), but no differences in IRAK-2 expression were detected compared to controls. miR-146a, -155 and -21 expressions were increased in LC-HR (P = 0.04, 0.07, and 0.004) and UC (P = 0.02, 0.04 and 0.03) patients. miR-146a and miR-21 expressions were significantly enhanced in UC patients compared to UC remission (UC-R; P = 0.01 and 0.04). Likewise, active CC patients showed significantly increased expression of miR-155 (P = 0.003) and miR-21 (P = 0.006). IL-37 expression was decreased in both CC (P = 0.03) and LC (P = 0.04) patients with a similar trend in UC patients but not statistically significant, whilst it was increased in UC-R patients compared to controls (P = 0.02) and active UC (P = 0.001).
conclusionThe identification of differentially expressed miRNAs, IL-37, and IRAK-M suggests different pathophysiologic mechanisms in various disease stages in LC, CC, and UC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.