Evidence map›Paper›PMID 25232236›Full record

ReviewWorld journal of gastroenterology2014

Methylation-mediated gene silencing as biomarkers of gastric cancer: a review.

Jun Nakamura, Tomokazu Tanaka, Yoshihiko Kitajima, Hirokazu Noshiro, Kohji Miyazaki

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Changing trends in the epidemiology of gastric cancer.Medicine and pharmacy reports · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth.Journal of experimental & clinical cancer research : CR · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Journal of Cancer · 2018
    Article
  16. Article
  17. Observational
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jun NakamuraJun Nakamura, Tomokazu Tanaka, Yoshihiko Kitajima, Hirokazu Noshiro, Kohji Miyazaki, Department of Surgery, Saga University Faculty of Medicine, Saga 849-8501, Japan.
Tomokazu TanakaJun Nakamura, Tomokazu Tanaka, Yoshihiko Kitajima, Hirokazu Noshiro, Kohji Miyazaki, Department of Surgery, Saga University Faculty of Medicine, Saga 849-8501, Japan.
Yoshihiko KitajimaJun Nakamura, Tomokazu Tanaka, Yoshihiko Kitajima, Hirokazu Noshiro, Kohji Miyazaki, Department of Surgery, Saga University Faculty of Medicine, Saga 849-8501, Japan.
Hirokazu NoshiroJun Nakamura, Tomokazu Tanaka, Yoshihiko Kitajima, Hirokazu Noshiro, Kohji Miyazaki, Department of Surgery, Saga University Faculty of Medicine, Saga 849-8501, Japan.
Kohji MiyazakiJun Nakamura, Tomokazu Tanaka, Yoshihiko Kitajima, Hirokazu Noshiro, Kohji Miyazaki, Department of Surgery, Saga University Faculty of Medicine, Saga 849-8501, Japan.
Saga University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite a decline in the overall incidence of gastric cancer (GC), the disease remains the second most common cause of cancer-related death worldwide and is thus a significant global health problem. The best means of improving the survival of GC patients is to screen for and treat early lesions. However, GC is often diagnosed at an advanced stage and is associated with a poor prognosis. Current diagnostic and therapeutic strategies have not been successful in decreasing the global burden of the disease; therefore, the identification of reliable biomarkers for an early diagnosis, predictive markers of recurrence and survival and markers of drug sensitivity and/or resistance is urgently needed. The initiation and progression of GC depends not only on genetic alterations but also epigenetic changes, such as DNA methylation and histone modification. Aberrant DNA methylation is the most well-defined epigenetic change in human cancers and is associated with inappropriate gene silencing. Therefore, an increasing number of genes methylated at the promoter region have been targeted as possible biomarkers for different purposes, including early detection, classification, the assessment of the tumor prognosis, the development of therapeutic strategies and patient follow-up. This review article summarizes the current understanding and recent evidence regarding DNA methylation markers in GC with a focus on the clinical potential of these markers.

Indexed as

DNA MethylationGene SilencingGenetic TestingAnimalsAntineoplastic AgentsBiomarkers, TumorDrug Resistance, NeoplasmEarly Detection of CancerGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHumansPatient SelectionPharmacogeneticsPhenotypePrecision MedicinePredictive Value of TestsAntineoplastic AgentsBiomarkers, TumorBiomarkerDrug sensitivityEarly detectionGastric cancerMethylation

Identifiers

PMID25232236
PMCPMC4161787
OpenAlexW2032563963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.