ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2014
Correlation of ADC value with pathologic indexes in colorectal tumor homografts in Balb/c mouse.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 14 citations in OpenAlex.
- The relationship between the apparent diffusion coefficient and the Ki-67 proliferation index in intracranial solitary fibrous tumor/hemangiopericytoma.Neurosurgical review · 2022Article
- Correlations between intravoxel incoherent motion (IVIM) parameters and histological findings in rectal cancer: preliminary results.Oncotarget · 2017Article
- Use of non-invasive imaging to monitor response to aflibercept treatment in murine models of colorectal cancer liver metastases.Clinical & experimental metastasis · 2017Article
- Free-breathing 3D diffusion MRI for high-resolution hepatic metastasis characterization in small animals.Clinical & experimental metastasis · 2016Article
- Fluorouracil-based preoperative chemoradiotherapy with or without oxaliplatin for stage II/III rectal cancer: a 3-year follow-up study.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2015Article
- Biomarkers in preclinical cancer imaging.European journal of nuclear medicine and molecular imaging · 2015Review
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4 authors at 1 institution in 1 country.
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Abstract
objectiveNoninvasive diffusion-weighted magnetic resonance imaging (DWI) is a well-studied MR imaging technique for quantifying water diffusion especially in tumor area. The correlation between apparent diffusion coefficient (ADC) value and apoptosis or proliferation is not clear by now. This study aimed to investigate whether DWI-ADC value could be used as an imaging marker related with pathologic indexes of tumors.
methodsA total of 30 Balb/c mice with HT29 colorectal carcinoma were subjected to DWI and histologic analysis. The percentage of ADC changes and the apoptotic and proliferating indexes were calculated at predefined time points. Kolmogorov-Smirnov distances were considered to determine whether the percentage of ADC changes, and the apoptotic and proliferating indexes were normally distributed. An independent-samples t-test was used to analyze the difference between apoptotic and proliferating indexes in the two groups.
resultsTHERE WAS A STATISTICALLY SIGNIFICANT DIFFERENCE IN PROLIFERATING INDEX BETWEEN THE RADIOTHERAPY AND CONTROL GROUPS (MEAN PROLIFERATING INDEX: 49.27% vs. 83.09%), and there was a statistically significant difference in apoptotic index between the two groups (mean apoptotic index: 37.7% vs. 2.71%). A significant positive correlation was found between the percentage of ADC changes of the viable tissue and apoptotic index. Pearson's correlation coefficient was 0.655 (P=0.015). A significant negative correlation was found between the percentage of ADC changes of the viable tissue and ki-67 proliferation index. Pearson's correlation coefficient was 0.734 (P<0.001).
conclusionsOur results suggest that ADC value may be used in measurement of cell apoptotic and proliferating indexes in colorectal carcinoma.
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