Evidence map›Paper›PMID 25232209›Full record

ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2014

In vitro effect of iASPP on cell growth of oral tongue squamous cell carcinoma.

Yu Chen, Wangxiang Yan, Shuqi He, Jiechun Chen, Dan Chen, Zhaoqiang Zhang, Zhiguo Liu, Xueqiang Ding, Anxun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yu Chen1 Department of Oral & Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China, 2 Department of Stomatology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China ; 3 Operation Room, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China ; 4 Department of Stomatology, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Wangxiang Yan1 Department of Oral & Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China, 2 Department of Stomatology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China ; 3 Operation Room, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China ; 4 Department of Stomatology, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Shuqi He1 Department of Oral & Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China, 2 Department of Stomatology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China ; 3 Operation Room, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China ; 4 Department of Stomatology, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Jiechun Chen1 Department of Oral & Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China, 2 Department of Stomatology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China ; 3 Operation Room, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China ; 4 Department of Stomatology, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Dan Chen1 Department of Oral & Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China, 2 Department of Stomatology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China ; 3 Operation Room, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China ; 4 Department of Stomatology, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Zhaoqiang Zhang1 Department of Oral & Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China, 2 Department of Stomatology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China ; 3 Operation Room, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China ; 4 Department of Stomatology, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Zhiguo Liu1 Department of Oral & Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China, 2 Department of Stomatology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China ; 3 Operation Room, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China ; 4 Department of Stomatology, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Xueqiang Ding1 Department of Oral & Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China, 2 Department of Stomatology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China ; 3 Operation Room, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China ; 4 Department of Stomatology, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Anxun Wang1 Department of Oral & Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China, 2 Department of Stomatology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China ; 3 Operation Room, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China ; 4 Department of Stomatology, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

iASPP is an inhibitory member of the apoptosis-stimulating proteins of P53 (ASPP) family. iASPP is over expressed in several malignant tumors and potentially affects cancer progression. However, the expression and potential role of iASPP in oral tongue squamous cell carcinoma (OTSCC) have not been addressed. In our study, we detected iASPP expression in OTSCC by immunohistochemistry. iASPP expression is up-regulated in OTSCC tissues. Moreover, in clinical pathology specimens, we found that increased iASPP expression correlates with poor differentiation and lymph node metastasis. Using multicellular tumor spheroids (MTS) and flow cytometry, we demonstrated that iASPP down-regulation arrests OTSCC cells at the G0/G1 phase, induces OTSCC cell apoptosis and inhibits OTSCC cell proliferation. These results indicate that iASPP plays a significant role in the progression of OTSCC and may serve as a biomarker or therapeutic target for OTSCC patients.

Indexed as

apoptosisiASPPoral tongue squamous cell carcinoma (OTSCC)proliferation

Identifiers

PMID25232209
PMCPMC4153930
OpenAlexW2211449175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.