ArticleJournal of clinical microbiology2014
Identification of a novel RNA virus lethal to tilapia.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 351 citations in OpenAlex.
- Dietary β-Glucan From the Marine Diatom Chaetoceros muelleri Enhances Immune Responses and Resistance of Nile Tilapia to Tilapia Lake Virus Infection.Journal of fish diseases · 2026Article
- Uncovering host transcriptional responses to tilapia lake virus (TiLV) through De novo RNA-seq assembly in Nile tilapia, Oreochromis niloticus.Archives of virology · 2026Article
- In vitro replication efficiency of tilapia parvovirus (TiPV) using different fish cell lines.In vitro cellular & developmental biology. Animal · 2026Article
- Evaluation of systemic and mucosal immune responses in Nile tilapia following intraperitoneal and immersion vaccination with inactivated tilapia lake virus (TiLV) vaccine.Scientific reports · 2026Article
- Prophylactic and Immunomodulatory potential of gooseberry (Phyllanthus acidus) and oregano (Coleus amboinicus) extracts against tilapia lake virus (TiLV) in tilapia.Archives of virology · 2026Article
- Phylogenetic and Proteomic Analyses of Segment 2 Sequence Reveals the Presence of Two Variants of a Divergent Amnoonvirus (Family:Microorganisms · 2026Article
- Genome sequencing and analysis of kuchijirosho virus identify it as a novel member of the family Amnoonviridae within the order Articulavirales.Archives of virology · 2026Article
- Characterisation of the tilapia lake virus proteome and identification of an 11th protein, S9-F3.Npj viruses · 2026Article
- Dynamics of Tilapia Lake Virus in Recirculating Aquaculture Systems and the Impact of Vaccination on Outbreak Control.Viruses · 2026Article
- Fine mapping and functional annotation of a QTL for resistance to tilapia lake virus in Nile tilapia (Oreochromis niloticus).G3 (Bethesda, Md.) · 2026Article
- Article
- Exploring the Virome of Nile Tilapia (Pathogens (Basel, Switzerland) · 2025Article
- Tilapia Lake Virus (TiLV), Aeromonas caviae and aquatic environmental variation- the triad stressors lead mass mortality in Oreochromis niloticus in wetlands of West Bengal, India.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Development of Reverse Transcriptase Recombinase Polymerase Amplification Combined with Lateral Flow Dipstick for Rapid Detection of Tilapia Lake Virus (TiLV): Pilot Study.Veterinary sciences · 2025Article
- Environmental variability and pathogen synergy influencing tilapia lake virus outbreaks on tilapia farms in Tamil Nadu, India.Archives of virology · 2025Article
- Article
- The snakehead retrovirus promoter functions independently of the 3'ORF protein and its products are maternally inherited in transgenic zebrafish.PLoS pathogens · 2025Article
- Review
- Detection of Tilapia parvovirus in farm-reared tilapia in India and its isolation using fish cell lines.In vitro cellular & developmental biology. Animal · 2025Article
- Investigation of Tilapia (Oreochromis niloticus) Mortality Events Targeting Tilapia Lake Virus Disease (TiLVD) in Bangladesh.Veterinary medicine and science · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tilapines are important for the sustainability of ecological systems and serve as the second most important group of farmed fish worldwide. Significant mortality of wild and cultured tilapia has been observed recently in Israel. The etiological agent of this disease, a novel RNA virus, is described here, and procedures allowing its isolation and detection are revealed. The virus, denominated tilapia lake virus (TiLV), was propagated in primary tilapia brain cells or in an E-11 cell line, and it induced a cytopathic effect at 5 to 10 days postinfection. Electron microscopy revealed enveloped icosahedral particles of 55 to 75 nm. Low-passage TiLV, injected intraperitoneally in tilapia, induced a disease resembling the natural disease, which typically presents with lethargy, ocular alterations, and skin erosions, with >80% mortality. Histological changes included congestion of the internal organs (kidneys and brain) with foci of gliosis and perivascular cuffing of lymphocytes in the brain cortex; ocular inflammation included endophthalmitis and cataractous changes of the lens. The cohabitation of healthy and diseased fish demonstrated that the disease is contagious and that mortalities (80 to 100%) occur within a few days. Fish surviving the initial mortality were immune to further TiLV infections, suggesting the mounting of a protective immune response. Screening cDNA libraries identified a TiLV-specific sequence, allowing the design of a PCR-based diagnostic test. This test enables the specific identification of TiLV in tilapines and should help control the spread of this virus worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.