ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
The recurrent case for the Renshaw cell.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Synaptic imbalance and increased inhibition impair motor function in SMA.Science advances · 2025Article
- Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.Cell reports · 2024Article
- Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.bioRxiv : the preprint server for biology · 2024Article
- Spinal Interneurons: Diversity and Connectivity in Motor Control.Annual review of neuroscience · 2023Review
- Blind identification of the spinal cord output in humans with high-density electrode arrays implanted in muscles.Science advances · 2022Article
- Article
- Spinal interneurons of the lower urinary tract circuits.Autonomic neuroscience : basic & clinical · 2021Review
- Spatial and Temporal Arrangement of Recurrent Inhibition in the Primate Upper Limb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Ventral root evoked entrainment of disinhibited bursts across early postnatal development in mice.IBRO reports · 2020Article
- Properties of Renshaw-like cells excited by recurrent collaterals of pudendal motoneurons in the cat.The journal of physiological sciences : JPS · 2020Article
- NeuroPath2Path: Classification and elastic morphing between neuronal arbors using path-wise similarity.Neuroinformatics · 2020Article
- Projection Neuron Axon Collaterals in the Dorsal Horn: Placing a New Player in Spinal Cord Pain Processing.Frontiers in physiology · 2020Review
- Central and peripheral innervation patterns of defined axial motor units in larval zebrafish.The Journal of comparative neurology · 2019Article
- Strong preference for autaptic self-connectivity of neocortical PV interneurons facilitates their tuning to γ-oscillations.PLoS biology · 2019Article
- Feedback to the future: motor neuron contributions to central pattern generator function.The Journal of experimental biology · 2019Review
- Article
- Motor units as tools to evaluate profile of human Renshaw inhibition.The Journal of physiology · 2019Article
- Subtype Diversification and Synaptic Specificity of Stem Cell-Derived Spinal Interneurons.Neuron · 2018Article
- Sub-populations of Spinal V3 Interneurons Form Focal Modules of Layered Pre-motor Microcircuits.Cell reports · 2018Article
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6 authors.
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Abstract
Although Renshaw cells (RCs) were discovered over half a century ago, their precise role in recurrent inhibition and ability to modulate motoneuron excitability have yet to be established. Indirect measurements of recurrent inhibition have suggested only a weak modulatory effect but are limited by the lack of observed motoneuron responses to inputs from single RCs. Here we present dual recordings between connected RC-motoneuron pairs, performed on mouse spinal cord. Motoneuron responses demonstrated that Renshaw synapses elicit large inhibitory conductances and show short-term potentiation. Anatomical reconstruction, combined with a novel method of quantal analysis, showed that the strong inhibitory input from RCs results from the large number of synaptic contacts that they make onto individual motoneurons. We used the NEURON simulation environment to construct realistic electrotonic models, which showed that inhibitory conductances from Renshaw inputs exert considerable shunting effects in motoneurons and reduce the frequency of spikes generated by excitatory inputs. This was confirmed experimentally by showing that excitation of a single RC or selective activation of the recurrent inhibitory pathway to generate equivalent inhibitory conductances both suppress motoneuron firing. We conclude that recurrent inhibition is remarkably effective, in that a single action potential from one RC is sufficient to silence a motoneuron. Although our results may differ from previous indirect observations, they underline a need for a reevaluation of the role that RCs perform in one of the first neuronal circuits to be discovered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.