Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Serotonin affects movement gain control in the spinal cord.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05465005 (Perception of Electrical Stimuli During Muscle Activation in Individuals With Stroke), which is not on this map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perception of Electrical Stimuli During Muscle Activation in Individuals With Stroke
Who cites it
64 citing papers in PubMed.
- 5-HTThe Journal of physiology · 2025Trial
- Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions.The Journal of physiology · 2019Trial
- Human motoneurone excitability is depressed by activation of serotonin 1A receptors with buspirone.The Journal of physiology · 2017Trial
- Exteroceptive Reflexes in Stiff Person Syndrome, Other Neurological Conditions and Healthy Controls.Movement disorders clinical practice · 2026Article
- Monoaminergic modulation of the relation between motor cortical activity and grip force.Journal of neurophysiology · 2026Article
- Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose-dependent manner.Experimental physiology · 2026Article
- Compensatory scaling of modulatory neural populations in response to motor challenges.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effects of arm-cycling exercise during triceps surae neuromuscular electrical stimulation on torque output and fatigue.European journal of applied physiology · 2026Article
- Influence of serotonin on the long-term muscle contraction of the Kohnstamm phenomenon.Scientific reports · 2025Article
- Intrinsic properties of spinal motoneurons degrade ankle torque control in humans.The Journal of physiology · 2025Article
- Unsupervised, piecewise linear decoding enables an accurate prediction of muscle activity in a multi-task brain computer interface.Journal of neural engineering · 2025Article
- Article
- Stressors affect human motor timing during spaceflight.NPJ microgravity · 2024Article
- Motoneuron persistent inward current contribution to increased torque responses to wide-pulse high-frequency neuromuscular electrical stimulation.European journal of applied physiology · 2024Article
- Unsupervised, piecewise linear decoding enables an accurate prediction of muscle activity in a multi-task brain computer interface.bioRxiv : the preprint server for biology · 2024Article
- Voluntary co-contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.The Journal of physiology · 2024Article
- Motor Cortex Latent Dynamics Encode Spatial and Temporal Arm Movement Parameters Independently.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Motor cortex latent dynamics encode spatial and temporal arm movement parameters independently.bioRxiv : the preprint server for biology · 2024Article
- Intrinsic motoneuron properties in typical human development.The Journal of physiology · 2024Article
- Voluntary co-contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.bioRxiv : the preprint server for biology · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
A fundamental challenge for the nervous system is to encode signals spanning many orders of magnitude with neurons of limited bandwidth. To meet this challenge, perceptual systems use gain control. However, whether the motor system uses an analogous mechanism is essentially unknown. Neuromodulators, such as serotonin, are prime candidates for gain control signals during force production. Serotonergic neurons project diffusely to motor pools, and, therefore, force production by one muscle should change the gain of others. Here we present behavioral and pharmaceutical evidence that serotonin modulates the input-output gain of motoneurons in humans. By selectively changing the efficacy of serotonin with drugs, we systematically modulated the amplitude of spinal reflexes. More importantly, force production in different limbs interacts systematically, as predicted by a spinal gain control mechanism. Psychophysics and pharmacology suggest that the motor system adopts gain control mechanisms, and serotonin is a primary driver for their implementation in force production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.