ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2014
Investigation into celiac disease in Indian patients with portal hypertension.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- What makes non-cirrhotic portal hypertension a common disease in India? Analysis for environmental factors.The Indian journal of medical research · 2019Review
- Prevalence of celiac disease among pediatric patients with cryptogenic cirrhosis and effect of gluten-free-diet.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Observational
- Spectrum of histopathological changes in patients with non-cirrhotic portal fibrosis.Hepatology international · 2018Article
- Idiopathic portal hypertension and extrahepatic portal venous obstruction.Hepatology international · 2018Review
- ADAMTS13 missense variants associated with defective activity and secretion of ADAMTS13 in a patient with non-cirrhotic portal hypertension.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Article
- To screen or not to screen? Celiac antibodies in liver diseases.World journal of gastroenterology · 2017Review
- Arsenicosis, possibly from contaminated groundwater, associated with noncirrhotic intrahepatic portal hypertension.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Article
- Portal hypertension and celiac disease: a true association?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Article
- Gut-liver axis and disease infidelity: a subject worth exploring.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2014Article
- Celiac Disease and Portal Hypertension: A Causal Association or Just a Coincidence?Journal of clinical and experimental hepatologyArticle
- Frequency of Non-cirrhotic Portal Fibrosis in Patients with Celiac Disease: A Single Center Experience From Northern India.Journal of clinical and experimental hepatologyArticle
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15 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is limited data on celiac disease in patients with cryptogenic cirrhosis or idiopathic noncirrhotic intrahepatic portal hypertension (NCIPH). Our objective was to evaluate for celiac disease in patients with portal hypertension in India.
methodsConsecutive patients with portal hypertension having cryptogenic chronic liver disease (cases) and hepatitis B- or C-related cirrhosis (controls) were prospectively enrolled. We studied tissue transglutaminase (tTG) antibody and duodenal histology in study patients.
resultSixty-one cases (including 14 NCIPH patients) and 59 controls were enrolled. Celiac disease was noted in six cases (including two NCIPH patients) as compared to none in controls. In a significant proportion of the remaining study subjects, duodenal biopsy showed villous atrophy, crypt hyperplasia, and lamina propria inflammation, not accompanied by raised intraepithelial lymphocytes (IELs); this was seen more commonly in cases as compared to controls. An unexpectedly high rate of tTG antibody positivity was seen in study subjects (66 %) of cases as compared to 29 % in controls (p-value < 0.001), which could indicate false-positive test result.
conclusionIn this study, 10 % of patients with unexplained portal hypertension (cryptogenic chronic liver disease) had associated celiac disease. In addition, an unexplained enteropathy was seen in a significant proportion of study patients, more so in patients with cryptogenic chronic liver disease. This finding warrants further investigation.
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