ArticleLasers in medical science2015
Effect of LLLT on endothelial cells culture.
Article in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- The Effect of injectable platelet-rich fibrin and low-level laser therapy on graft shrinkage in free gingival grafts: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Effect of the transdermal low-level laser therapy on endothelial function.Lasers in medical science · 2016Trial
- Photobiomodulation at 660 nm enhances proliferative activity while preserving viability in human endothelial cells in vitro.Cell and tissue banking · 2026Article
- The effect of different time intervals of diode laser irradiation on the in Ovo chick embryo yolk sac membrane for angiogenic differentiation - an in Ovo pilot experimental study.Lasers in medical science · 2025Article
- Photobiomodulatory Effects of Low-Power LED Light on Cultured Human Umbilical Vein Endothelial Cells.Journal of clinical medicine · 2025Article
- Effects of NGF and Photobiomodulation Therapy on Crush Nerve Injury and Fracture Healing: A Stereological and Histopathological Study in an Animal Model.Craniomaxillofacial trauma & reconstruction · 2023Article
- Biomodulator of Diode Laser Irradiation on Odontoblast-Like Cells by Expression of Vascular Endothelial Growth Factor-A and Transforming Growth Factor-β1.European journal of dentistry · 2023Article
- Effects of photobiomodulation as an adjunctive treatment in chronic obstructive pulmonary disease: a narrative review.Lasers in medical science · 2023Review
- Low-Level Laser Therapy Induces Melanoma Tumor Growth by Promoting Angiogenesis.Life (Basel, Switzerland) · 2023Article
- Experimental and Clinical Applications of Red and Near-Infrared Photobiomodulation on Endothelial Dysfunction: A Review.Biomedicines · 2021Review
- Photobiomodulation alters the viability of HUVECs cells.Lasers in medical science · 2021Article
- Dosage Effects of an 810 nm Diode Laser on the Proliferation and Growth Factor Expression of Human Gingival Fibroblasts.Journal of lasers in medical sciences · 2021Article
- In Vitro Cytological Responses against Laser Photobiomodulation for Periodontal Regeneration.International journal of molecular sciences · 2020Review
- Phototherapy as a Rational Antioxidant Treatment Modality in COVID-19 Management; New Concept and Strategic Approach: Critical Review.Antioxidants (Basel, Switzerland) · 2020Review
- Photobiomodulation with 808-nm diode laser light promotes wound healing of human endothelial cells through increased reactive oxygen species production stimulating mitochondrial oxidative phosphorylation.Lasers in medical science · 2019Article
- Low-level laser irradiation at a high power intensity increased human endothelial cell exosome secretion via Wnt signaling.Lasers in medical science · 2018Article
- Laser phototherapy induces angiogenesis in the periodontal tissue after delayed tooth replantation in rats.Journal of clinical and experimental dentistry · 2018Article
- Low-level laser therapy prevents endothelial cells from TNF-α/cycloheximide-induced apoptosis.Lasers in medical science · 2018Article
- Scattering and absorption control in biocompatible fibers towards equalized photobiomodulation.Biomedical optics express · 2017Article
- Low-level laser irradiation effect on endothelial cells under conditions of hyperglycemia.Lasers in medical science · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth factors as vascular endothelial growth factor (VEGF), produced by the endothelial cells, take an essential part in pathological and physiological angiogenesis. The possibility of angiogenesis modulation by application of laser radiation may contribute to the improvement of its use in this process. Thus, the aim of the study was to investigate the influence of low-level laser therapy (LLLT) on the proliferation of endothelial cells, secretion of VEGF-A and presence of soluble VEGF receptors (sVEGFR-1 and sVEGFR-2) in the medium after in vitro culture. Isolated human umbilical vein endothelial cells (HUVECs) were irradiated using a diode laser at a wavelength of 635 nm and power density of 1,875 mW/cm(2). Depending on radiation energy density, the experiment was conducted in four groups: I 0 J/cm(2) (control group), II 2 J/cm(2), III 4 J/cm(2), and IV 8 J/cm(2). The use of laser radiation wavelength of 635 nm, was associated with a statistically significant increase in proliferation of endothelial cells (p = 0.0041). Moreover, at 635-nm wavelength, all doses of radiation significantly reduced the concentration of sVEGFR-1 (p = 0.0197).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.