ArticleNeurocritical care2015
Hypernatremia is a significant risk factor for acute kidney injury after subarachnoid hemorrhage: a retrospective analysis.
Article in Neurocritical care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Korean Society of Nephrology 2025 evidence-based clinical practice guideline for continuous kidney replacement therapy.Kidney research and clinical practice · 2026Article
- Korean Society of Nephrology 2025 Evidence-Based Clinical Practice Guideline for Continuous Kidney Replacement Therapy.Electrolyte & blood pressure : E & BP · 2026Review
- Factors and outcomes associated with acute kidney injury in brain tumor resection patients: insights from a large US database (2010-2019).Renal failure · 2025Article
- A machine learning predictive model for acute kidney injury among aneurysmal subarachnoid hemorrhage patients.BMC medical informatics and decision making · 2025Article
- Development and Validation of a Machine Learning Model for Early Prediction of Acute Kidney Injury in Neurocritical Care: A Comparative Analysis of XGBoost, GBM, and Random Forest Algorithms.Diagnostics (Basel, Switzerland) · 2025Article
- Association between triglyceride-glucose index and risk of acute kidney injury in patients with aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2025Article
- Association between serum phosphate level and mortality of patients with aneurysmal subarachnoid hemorrhage.Neurosurgical review · 2024Article
- Observational
- Association between serum calcium level and the risk of acute kidney injury in ICU patients with subarachnoid hemorrhage: a retrospective cohort study.Frontiers in neurology · 2024Article
- A prognostic model incorporating the albumin-corrected anion gap in patients with aneurysmal subarachnoid hemorrhage.Frontiers in neurology · 2024Article
- Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosis.Renal failure · 2023Article
- Acute kidney injury in neurocritical care.Critical care (London, England) · 2023Review
- Hypernatremia: Epidemiology and Predictive Role in Emerging and Established Acute Kidney Injury.Journal of clinical medicine research · 2023Review
- Prevention and Correction of Dysnatremia After Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2023Review
- Association of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Acute Kidney Injury at the Neurocritical Care Unit.Neurocritical care · 2022Review
- Plasma anion gap and risk of in-hospital mortality in patients with spontaneous subarachnoid hemorrhage.Frontiers in neurology · 2022Article
- A nomogram based on serum cystatin C for predicting acute kidney injury in patients with traumatic brain injury.Renal failure · 2021Observational
- Association Between Serum Osmolality and Acute Kidney Injury in Critically Ill Patients: A Retrospective Cohort Study.Frontiers in medicine · 2021Article
- Risk Scoring Systems Including Electrolyte Disorders for Predicting the Incidence of Acute Kidney Injury in Hospitalized Patients.Clinical epidemiology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertonic saline therapy is often used in critically ill subarachnoid hemorrhage (SAH) patients for indications ranging from control of intracranial hypertension to managing symptomatic hyponatremia. The risk factors for developing acute kidney injury (AKI) in this patient population are not well defined. SPECIFIC
aimTo study the role of serum sodium in developing AKI (based on the AKIN definition) in the SAH population admitted to a large academic neurocritical care unit.
methodsThis is an IRB-approved, retrospective cohort study of patients admitted to a tertiary neuro intensive care unit. We included adult (age ≥ 18 years) SAH patients admitted to the neuro intensive care unit for at least 72 h. Development of AKI after admission to the ICU was defined using the AKIN serum creatinine criteria between 72 h and 14 days following admission. A Cox proportional hazards survival model with multiple time varying covariates was developed to evaluate the effect of maximum sodium exposure on the risk of AKI. Sodium exposure was captured as the running maximum of daily maximum serum sodium concentration (mEq/L). Sodium exposure was used as a surrogate for hypertonic saline therapy.
resultsThe final cohort of patients included 736 patients admitted to the neuro intensive care unit between 2006 and 2012. The number of patients who developed AKI was 64 (9 %). These patients had an increased length of stay (15.6 ± 9.4 vs. 12.5 ± 8.7 days). The odds of death were more than two fold greater among patients who developed AKI (odds ratio 2.33 95 % CI 1.27, 4.3). Sodium exposure was significantly associated with the hazard of developing AKI, adjusting for age, sex, preexisting renal disease, diabetes mellitus, radiocontrast exposure, number of days on mechanical ventilation, and admission Glasgow Coma Scale score. For each 1 mEq/L increase in the running maximum daily serum sodium, the hazard of developing AKI was increased by 5.4 % (95 % CI 1.4, 9.7).
conclusionThe maximum daily sodium is a significant risk factor for developing AKI in patients with SAH.
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