ArticleBMC women's health2014
Effects of interval between age at first pregnancy and age at diagnosis on breast cancer survival according to menopausal status: a register-based study in Korea.
Article in BMC women's health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Breast Cancer Molecular Subtypes and Receptor-Related Risk Factor Associations: A Cross-Sectional Study.Health science reports · 2026Article
- Reproductive history and breast cancer survival: Findings from the African breast cancer-Disparities in outcomes cohort and implications of Africa's fertility transition on breast cancer prognosis.International journal of cancer · 2023Article
- A Historical Misconception in Clinical Trials of Drugs for Cancer-Age Grouping.Journal of personalized medicine · 2022Article
- Age at Diagnosis of Breast Cancer in Iran: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2021Review
- Article
- Associations of reproductive factors with breast cancer prognosis and the modifying effects of menopausal status.Cancer medicine · 2020Observational
- Comparison Cure Rate Models by DIC Criteria in Breast Cancer DataAsian Pacific journal of cancer prevention : APJCP · 2018Article
- The Effect of Reproductive Factors on Breast Cancer Presentation in Women Who AreJournal of breast cancer · 2017Article
- Human Chorionic Gonadotropin and Breast Cancer.International journal of molecular sciences · 2017Review
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe influence of parity and time interval between age at first pregnancy (AFP) and age at diagnosis on breast cancer survival is not established in the same way as their influence on breast cancer risk. We aimed to investigate the association of time interval or parity with prognosis in pre- and postmenopausal women in Korea.
methodsWe conducted a retrospective study of 29,167 women with breast cancer through the Korean Breast Cancer Registry from 1993-2009. Information on reproductive factors, including breastfeeding, AFP, and parity were collected from a routine questionnaire. Conditional logistic regression was used to estimate the associations between menopausal status and overall mortality (OM) and breast-cancer-specific mortality (BCSM), adjusting for treatment and stage.
resultsHigh parity (≥5) increased the hazard ratios (HR) of BCSM (HR = 1.33, 95% confidence interval (CI): 0.83-2.11, p < 0.001) and OM (HR = 1.20, 95% CI: 0.85-1.68.73, p < 0.001) in premenopausal and postmenopausal women (BCSM, HR: 1.62, 95% CI: 0.93-2.82, p < 0.001; OM, HR = 1.58, 95% CI: 1.14-2.21, p <0.001). A longer time interval between age at breast cancer diagnosis and AFP reduced the HRs of BCSM (HR = 0.97, 95% CI: 0.96-0.98, p = 0.001) and OM (HR = 0.98, 95% CI: 0.97-0.98, p < 0.001) in premenopausal women, but had an adverse effect on the HR of OM (HR = 1.03, 95% CI: 1.02-1.03, p < 0.001) in postmenopausal women.
conclusionsHigh parity (≥5) was associated with poor breast cancer prognosis in both pre- and postmenopausal women. The time intervals between reproductive events had different effects on breast cancer outcomes depending on menopausal status.
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