Evidence map›Paper›PMID 25231353›Full record

ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2014

Therapeutic potential of intermittent hypoxia: a matter of dose.

Angela Navarrete-Opazo, Gordon S Mitchell

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04281264 (Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly), which is not on this map. Cited by 272 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
272citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04281264 nacompletednot on this mapstarted 2019, after this paper: background citation

Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly

TypeinterventionalSponsorUniversity of ExtremaduraRan2019 to 2021Enrolled120ConditionsAging WellArmsPassive Hypoxia, Normoxia Circuit Training with Elastic Bands, Hypoxia Circuit Training with Elastic Bands, Normoxia Vibration, Hypoxia Vibration
3 · Its place in the literature

Who cites it

272 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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212 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Angela Navarrete-OpazoDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin.
Gordon S MitchellDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin Mitchell@svm.vetmed.wisc.edu.

Funding

Respiratory plasticity and spinal cord InjuryR37HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2002 to 2011
$4.2M
Mechanisms of respiratory long-term facilitationR01HL080209 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2005 to 2013
$2.9M
Respiratory Plasticity and Spinal Cord InjuryR01HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL069064NHLBI NIH HHS R01 HL-080209NHLBI NIH HHS R37 HL-69064
6 · The paper itself

Abstract

Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and triggers a bewildering array of both detrimental and beneficial effects in multiple physiological systems. Here, we review the extensive literature concerning IH and its impact on the respiratory, cardiovascular, immune, metabolic, bone, and nervous systems. One major goal is to define relevant IH characteristics leading to safe, protective, and/or therapeutic effects vs. pathogenesis. To understand the impact of IH, it is essential to define critical characteristics of the IH protocol under investigation, including potentially the severity of hypoxia within episodes, the duration of hypoxic episodes, the number of hypoxic episodes per day, the pattern of presentation across time (e.g., within vs. consecutive vs. alternating days), and the cumulative time of exposure. Not surprisingly, severe/chronic IH protocols tend to be pathogenic, whereas any beneficial effects are more likely to arise from modest/acute IH exposures. Features of the IH protocol most highly associated with beneficial vs. pathogenic outcomes include the level of hypoxemia within episodes and the number of episodes per day. Modest hypoxia (9-16% inspired O2) and low cycle numbers (3-15 episodes per day) most often lead to beneficial effects without pathology, whereas severe hypoxia (2-8% inspired O2) and more episodes per day (48-2,400 episodes/day) elicit progressively greater pathology. Accumulating evidence suggests that "low dose" IH (modest hypoxia, few episodes) may be a simple, safe, and effective treatment with considerable therapeutic potential for multiple clinical disorders.

Indexed as

AnimalsBone and BonesCardiovascular SystemHumansHypoxiaInflammationNervous SystemOxygenRespiratory SystemTime FactorsOxygendoseintermittent hypoxiapathogenicreviewtherapeutic

Identifiers

PMID25231353
PMCPMC4315448

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.