ArticleIntensive care medicine2015
Pulse oximetry vs. PaO2 metrics in mechanically ventilated children: Berlin definition of ARDS and mortality risk.
Article in Intensive care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 134 citations in OpenAlex.
- High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study).Intensive care medicine · 2017Trial
- Role of Oxygen Saturation Index as a Noninvasive Surrogate Marker of Oxygenation in Intubated Critically Ill Adult Patients: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Can the Oxygen Saturation Index Predict Severe Bronchopulmonary Dysplasia?Children (Basel, Switzerland) · 2025Article
- Correlation and predictive value of oxygenation and oxygen saturation indices in extremely preterm infants: a prospective study.Frontiers in pediatrics · 2025Article
- Noninvasive estimation of oxygenation index in pediatric critical care: an independent retrospective observational validation.Frontiers in pediatrics · 2025Article
- An Overview of Pediatric Pulmonary Complications During COVID-19 Pandemic: A Lesson for Future.Immunity, inflammation and disease · 2024Review
- Novel Oxygenation and Saturation Indices for Mortality Prediction in COVID-19 ARDS Patients: The Impact of Driving Pressure and Mechanical Power.Journal of intensive care medicine · 2024Article
- Associations between oxygen saturation Index and oxygenation index in neonates with congenital diaphragmatic hernia.Frontiers in pediatrics · 2024Article
- The value of lung ultrasound score in neonatal respiratory distress syndrome: a prospective diagnostic cohort study.Frontiers in medicine · 2024Article
- Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study.Journal of intensive care · 2023Article
- Correlation and Prognostic Significance of Oxygenation Indices in Invasively Ventilated Adults (OXIVA-CARDS) with COVID-19-associated ARDS: A Retrospective Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Noninvasive Oxygenation Indices: New Tools for Resource-limited Settings?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Pediatric in-hospital cardiac arrest: Respiratory failure characteristics and association with outcomes.Resuscitation · 2023Article
- Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome.Nature communications · 2023Article
- Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome.The Lancet. Respiratory medicine · 2022Review
- Sivelestat improves clinical outcomes and decreases ventilator-associated lung injury in children with acute respiratory distress syndrome: a retrospective cohort study.Translational pediatrics · 2022Article
- [Early risk factors for death in neonates with persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Clinical review of High Flow Nasal Cannula and Continuous Positive Airway Pressure in pediatric acute respiratory distress.Annals of medicine and surgery (2012) · 2022Review
- Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2021Review
- Estimated PaoCritical care explorations · 2021Article
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8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRequiring PaO2/FiO2 ratio (PF) to define ARDS may bias towards children with cardiovascular dysfunction and hypoxemia. We sought to evaluate (1) the Berlin definition of ARDS in children using PF; (2) the effect of substituting SpO2/FiO2(SF) ratio; (3) differences between patients with and without arterial blood gases; and (4) the ability of SpO2 and PaO2 indices to discriminate ICU mortality.
methodsSingle center retrospective review (3/2009-4/2013) of mechanically ventilated (MV) children. Initial values for PF, SF, oxygenation index (OI), and oxygen saturation index (OSI) after intubation and average values on day 1 of MV were analyzed against ICU mortality, subgrouped by Berlin severity categories.
resultsOf the 1,833 children included, 129 met Berlin PF ARDS criteria (33 % mortality); 312 met Berlin SF ARDS criteria (22 % mortality). Children with a PaO2 on day 1 of MV had higher mortality and severity of illness, were older, and had more vasoactive-inotropic infusions (p < 0.001). SF could be calculated for 1,201 children (AUC for ICU mortality 0.821), OSI for 1,034 (0.793), PF for 695 (0.706), and OI for 673 (0.739). Average SF on day 1 discriminated mortality better than PF (p = 0.003).
conclusionsBerlin PF criteria for ARDS identified less than half of the children with ARDS, favoring those with cardiovascular dysfunction. SF or OSI discriminate ICU mortality as well as PF and OI, double the number of children available for risk stratification, and should be considered for severity of illness scores and included in a pediatric-specific definition of ARDS. Multicenter validation is required.
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