ArticleNanotoxicology2015
Persistence of silver nanoparticles in the rat lung: Influence of dose, size, and chemical composition.
Article in Nanotoxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review.Particle and fibre toxicology · 2023Pooled it
- Platelet-Rich Plasma (PRP) Mitigates Silver Nanoparticle (AgNP)-Induced Pulmonary Fibrosis via iNOS/CD68/CASP3/TWIST1 Regulation: An Experimental Study and Bioinformatics Analysis.International journal of molecular sciences · 2025Article
- Zeolitic imidazolate framework-8: a versatile nanoplatform for tissue regeneration.Frontiers in bioengineering and biotechnology · 2024Review
- Comparative Evaluation of the Effects of Amorphous Silica Nanoparticles on the Erythrocytes of Wistar Normotensive and Spontaneously Hypertensive Rats.International journal of molecular sciences · 2023Article
- Macrophage-Targeted Nanomedicines for ARDS/ALI: Promise and Potential.Inflammation · 2022Review
- Advanced sanitation products infused with silver nanoparticles for viral protection and their ecological and environmental consequences.Environmental technology & innovation · 2022Review
- Effect of Triclosan and Silver Nanoparticles on DNA Damage Investigated with DNA-Based Biosensor.Sensors (Basel, Switzerland) · 2022Article
- An Update on Advancements and Challenges in Inhalational Drug Delivery for Pulmonary Arterial Hypertension.Molecules (Basel, Switzerland) · 2022Review
- Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure.International journal of molecular sciences · 2020Review
- Surface coatings alter transcriptional responses to silver nanoparticles following oral exposure.NanoImpact · 2020Article
- Antiviral and Immunomodulatory Activity of Silver Nanoparticles in Experimental RSV Infection.Viruses · 2019Article
- Bactericidal and Cytotoxic Properties of Silver Nanoparticles.International journal of molecular sciences · 2019Review
- Pulmonary and hepatic effects after low dose exposure to nanosilver: Early and long-lasting histological and ultrastructural alterations in rat.Toxicology reports · 2019Article
- The small airway epithelium as a target for the adverse pulmonary effects of silver nanoparticle inhalation.Nanotoxicology · 2018Article
- Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Pro-Inflammatory versus Immunomodulatory Effects of Silver Nanoparticles in the Lung: The Critical Role of Dose, Size and Surface Modification.Nanomaterials (Basel, Switzerland) · 2017Article
- Particle coatings but not silver ions mediate genotoxicity of ingested silver nanoparticles in a mouse model.NanoImpact · 2017Article
- Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats.Respiratory research · 2016Article
- Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time.Toxicologic pathology · 2016Article
- Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Increasing silver nanoparticle (AgNP) use in sprays, consumer products, and medical devices has raised concerns about potential health effects. While previous studies have investigated AgNPs, most were limited to a single particle size or surface coating. In this study, we investigated the effect of size, surface coating, and dose on the persistence of silver in the lung following exposure to AgNP. Adult male rats were intratracheally instilled with four different AgNPs: 20 or 110 nm in size and coated with either citrate or polyvinylpyrrolidone (PVP) at 0.5 or 1.0 mg/kg doses. Silver retention was assessed in the lung at 1, 7, and 21 d post exposure. ICP-MS quantification demonstrated that citrate-coated AgNPs persisted in the lung to 21 d with retention greater than 90%, while PVP-coated AgNP had less than 30% retention. Localization of silver in lung tissue at 1 d post exposure demonstrated decreased silver in proximal airways exposed to 110 nm particles compared with 20 nm AgNPs. In terminal bronchioles 1 d post exposure, silver was localized to surface epithelium but was more prominent in the basement membrane at 7 d. Silver positive macrophages in bronchoalveolar lavage fluid decreased more quickly after exposure to particles coated with PVP. We conclude that PVP-coated AgNPs had less retention in the lung tissue over time and larger particles were more rapidly cleared from large airways than smaller particles. The 20 nm citrate particles showed the greatest effect, increasing lung macrophages even 21 d after exposure, and resulted in the greatest silver retention in lung tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.