ArticleScientific reports2014
Pubertal onset in girls is strongly influenced by genetic variation affecting FSH action.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood.Scientific reports · 2016Trial
- Utility of First-Morning-Voided Urinary Total Luteinizing Hormone in Detecting the Onset of Central Puberty.Hormone research in paediatrics · 2026Article
- Circulating follicle stimulating hormone levels influence body growth in pre-menarcheal girls in a latitude-dependent manner.Heliyon · 2023Article
- Gene Polymorphisms Associated with Central Precocious Puberty and Hormone Levels in Chinese Girls.International journal of endocrinology · 2022Article
- Article
- Genetic and Epigenetic Control of Puberty.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022Review
- Levels of endocrine-disrupting chemicals are associated with changes in the peri-pubertal epigenome.Endocrine connections · 2020Article
- Age at onset of different pubertal signs in boys and girls and differential DNA methylation at age 10 and 18 years: an epigenome-wide follow-up study.Human reproduction open · 2020Article
- Gray Matter Differences Between Premature Pubertal Girls With and Without the Reactivation of the Hypothalamic-Pituitary-Gonadal Axis.Frontiers in psychiatry · 2020Article
- Genetics of pubertal timing.Current opinion in pediatrics · 2018Review
- TheEndocrine connections · 2018Article
- Adaptive capabilities and fitness consequences associated with pollution exposure in fish.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- DNA methylation of LINE-1 and Alu repetitive elements in relation to sex hormones and pubertal timing in Mexican-American children.Pediatric research · 2016Article
- Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.American journal of human genetics · 2016Article
- Nicotine and the adolescent brain.The Journal of physiology · 2015Review
- Longitudinal development of hormone levels and grey matter density in 9 and 12-year-old twins.Behavior genetics · 2015Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.
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