ArticleThe Journal of infectious diseases2015
Pneumocystis encodes a functional endo-β-1,3-glucanase that is expressed exclusively in cysts.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Immune Responses toJournal of inflammation research · 2026Review
- Axenic Long-Term Cultivation ofJournal of fungi (Basel, Switzerland) · 2023Article
- NovelJournal of fungi (Basel, Switzerland) · 2023Article
- Successful treatment of severeSAGE open medical case reports · 2023Article
- Targeting β-glucans, vital components of theFrontiers in immunology · 2023Review
- Characterization ofMicroorganisms · 2022Article
- Caspofungin combined with TMP/SMZ as a first-line therapy for moderate-to-severe PCP in patients with human immunodeficiency virus infection.HIV medicine · 2021Article
- A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.Clinical microbiology reviews · 2018Review
- Characterization of p57, a Stage-Specific Antigen of Pneumocystis murina.The Journal of infectious diseases · 2018Article
- Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation.Antimicrobial agents and chemotherapy · 2018Article
- Efficacy of caspofungin combined with trimethoprim/sulfamethoxazole as first-line therapy to treat non-HIV patients with severe pneumocystis pneumonia.Experimental and therapeutic medicine · 2018Article
- Morphology Changes in Human Fungal Pathogens upon Interaction with the Host.Journal of fungi (Basel, Switzerland) · 2017Article
- Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.Nature communications · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
β-1,3-glucan is a major cell wall component of Pneumocystis cysts. We have characterized endo-β-1,3-glucanase (Eng) from 3 species of Pneumocystis. The gene eng is a single-copy gene that encodes a protein containing 786 amino acids in P. carinii and P. murina, and 788 amino acids in P. jirovecii, including a signal peptide for the former 2 but not the latter. Recombinant Eng expressed in Escherichia coli was able to solubilize the major surface glycoprotein of Pneumocystis, thus potentially facilitating switching of the expressed major surface glycoprotein (Msg) variant. Confocal immunofluorescence analysis of P. murina-infected mouse lung sections localized Eng exclusively to the cyst form of Pneumocystis. No Eng was detected after mice were treated with caspofungin, a β-1,3-glucan synthase inhibitor that is known to reduce the number of cysts. Thus, Eng is a cyst-specific protein that may play a role in Msg variant expression in Pneumocystis.
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