Evidence map›Paper›PMID 25231015›Full record

ArticleThe Journal of infectious diseases2015

Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients.

Jonhan Ho, Jaroslaw J Jedrych, Huichen Feng, August A Natalie, Lisa Grandinetti, Ezra Mirvish, Maria M Crespo, Dhiraj Yadav, Kenneth E Fasanella, Siobhan Proksell and 6 more

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 108 citations in OpenAlex.

  1. Article
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  4. [Clues in dermatopathological diagnostics].Pathologie (Heidelberg, Germany) · 2025
    Review
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  7. Article
  8. [Human polyomavirus-associated skin diseases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Jonhan HoDepartment of Dermatology.
Jaroslaw J JedrychDepartment of Dermatology.
Huichen FengCancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania.
August A NatalieDepartment of Dermatology.
Lisa GrandinettiDepartment of Dermatology.
Ezra MirvishDepartment of Dermatology.
Maria M CrespoDivision of Pulmonary, Allergy, and Critical Care.
Dhiraj YadavDepartment of Medicine.
Kenneth E FasanellaDepartment of Medicine.
Siobhan ProksellDepartment of Medicine.
Shih-Fan KuanDepartment of Pathology, School of Medicine.
Diana V PastranaLaboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Christopher B BuckLaboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Yoko ShudaCancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania.
Patrick S MooreCancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania.
Yuan ChangCancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania.
UPMC Hillman Cancer Center · USNational Institutes of Health · USPulmonary and Allergy Associates · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
The internship in Biomedical Research, Informatics, and Computer Science (iBRIC): Biomedical Informatics and Data Science research experiences for students from Minority Serving InstitutionsT15LM007059 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRY S HOCHHEISER · 1987 to 2026
$23.9M
Molecular biology of human polyomavirusesZIABC011090 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BUCK, CHRISTOPHER · 2009 to 2025
$9.3M
Role of a New Polyomavirus in Merkel Cell CarcinomaR01CA136806 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOORE, PATRICK S. · 2009 to 2015
$3.0M
Protein Biomarkers for a New Human Polyomavirus in AIDS-related MalignanciesR01CA136363 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOORE, PATRICK S. · 2008 to 2015
$2.3M
Transcriptomic and Proteomic Approaches to Discovering Viral Causes for Human HemR01CA170354 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHANG, YUAN · 2012 to 2015
$1.3M
NCI NIH HHS CA136363NCI NIH HHS CA136806NCI NIH HHS CA170354NCI NIH HHS P30 CA047904NCI NIH HHS P30CA047904NCI NIH HHS R01 CA136363NCI NIH HHS R01 CA136806NCI NIH HHS R01 CA170354NLM NIH HHS 5T15LM007059-27NLM NIH HHS T15 LM007059
6 · The paper itself

Abstract

Human polyomavirus 7 (HPyV7) is one of 11 HPyVs recently discovered through genomic sequencing technologies. Two lung transplant recipients receiving immunosuppressive therapy developed pruritic, brown plaques on the trunk and extremities showing a distinctive epidermal hyperplasia with virus-laden keratinocytes containing densely packed 36-45-nm icosahedral capsids. Rolling circle amplification and gradient centrifugation testing were positive for encapsidated HPyV7 DNA in skin and peripheral blood specimens from both patients, and HPyV7 early and capsid proteins were abundantly expressed in affected tissues. We describe for the first time that HPyV7 is associated with novel pathogenicity in some immunosuppressed individuals.

Indexed as

Transplant RecipientsAgedBloodExanthemaHistocytochemistryHumansImmunocompromised HostImmunohistochemistryMaleMicroscopy, Electron, TransmissionPolyomavirusPolyomavirus InfectionsSkinTumor Virus InfectionsViremiaHPyV7immunosuppressionpolyomavirusskin viral infectiontransplantation-associated disease

Identifiers

PMID25231015
PMCPMC4425822
OpenAlexW2125860951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.