ArticleNeurology2014
Auras in generalized epilepsy.
Article in Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Pooled it
- Semiology of functional/dissociative seizures in idiopathic generalized epilepsy: An inpatient video-electroencephalographic study.Epilepsia · 2026Article
- Ictal body turning and version in generalized epilepsy.BMC neurology · 2026Article
- Distinct spike-and-wave EEG profiles reveal susceptibility to fleeting/almost loss of consciousness (so-called blips) in generalized epilepsy.Epilepsia · 2025Article
- Sex-specific proteomic analysis of epileptic brain tissues from Pten knockout mice and human refractory epilepsy.Experimental neurology · 2025Article
- A seizure in the eye of the beholder: painting an absence-to-bilateral-tonic-clonic seizure.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Headache Is a Common Aura in Patients with Generalized Seizures.Journal of epilepsy research · 2023Article
- Somatosensory Auras in Epilepsy: A Narrative Review of the Literature.Medicines (Basel, Switzerland) · 2023Review
- Non-convulsive epilepsy with acute-onset and short-lasting repeated fatigue attacks: A case of 30-year-old man.Journal of general and family medicine · 2022Article
- Headache in people with epilepsy.Nature reviews. Neurology · 2021Review
- Clinical and genomic analysis of a large Chinese family with familial cortical myoclonic tremor with epilepsy andEpilepsia open · 2021Article
- Stroboscopic light effects during electronic dance music festivals and photosensitive epilepsy: a cohort study and case report.BMJ open · 2019Article
- Ictal asystole with isolated syncope: A case report and literature review.Epilepsy & behavior case reports · 2019Article
- White Matter Abnormalities in Patients with Treatment-Resistant Genetic Generalized Epilepsies.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Auras Are Frequent in Patients With Generalized Epilepsy.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe studied the frequency of auras in generalized epilepsy (GE) using a detailed semistructured diagnostic interview.
methodsIn this cross-sectional study, participants with GE were drawn from the Epilepsy Phenome/Genome Project (EPGP). Responses to the standardized diagnostic interview regarding tonic-clonic (grand mal) seizures were then examined. This questionnaire initially required participants to provide their own description of any subjective phenomena before their "grand mal seizures." Participants who provided answers to these questions were considered to have an aura. All participants were then systematically queried regarding a list of specific symptoms occurring before grand mal seizures, using structured (closed-ended) questions.
resultsSeven hundred ninety-eight participants with GE were identified, of whom 530 reported grand mal seizures. Of these, 112 (21.3%) reported auras in response to the open-ended question. Analysis of responses to the closed-ended questions suggested that 341 participants (64.3%) experienced at least one form of aura.
conclusionsAuras typically associated with focal epilepsy were reported by a substantial proportion of EPGP subjects with GE. This finding may support existing theories of cortical and subcortical generators of GE with variable spread patterns. Differences between responses to the open-ended question and closed-ended questions may also reflect clinically relevant variation in patient responses to history-taking and surveys. Open-ended questions may underestimate the prevalence of specific types of auras and may be in part responsible for the underrecognition of auras in GE. In addition, structured questions may influence participants, possibly leading to a greater representation of symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.