Evidence map›Paper›PMID 25230997›Full record

ArticleNeurology2014

Midlife migraine and late-life parkinsonism: AGES-Reykjavik study.

Ann I Scher, G Webster Ross, Sigurdur Sigurdsson, Melissa Garcia, Larus S Gudmundsson, Sigurlaug Sveinbjörnsdóttir, Amy K Wagner, Vilmundur Gudnason, Lenore J Launer

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Article in Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

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22citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  6. Article
  7. Article
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  11. Lifelong Association of Disorders Related to Military Trauma with Subsequent Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ann I ScherFrom the Department of Preventive Medicine and Biometrics (A.I.S.), Uniformed Services University, Bethesda; National Institute on Aging (A.I.S., M.G., L.J.L.), Laboratory of Epidemiology and Population Sciences, Bethesda, MD; Veterans Affairs Pacific Islands Health Care System (G.W.R.), Honolulu; Pacific Health Research & Education Institute (G.W.R.), Honolulu, HI; Icelandic Heart Association (S. Sigurdsson, V.G.), Kopavogur; School of Health Sciences (L.S.G.) and Faculty of Medicine (V.G.), University of Iceland, Reykjavik; Department of Neurology (S. Sveinbjörnsdóttir), Broomfield Hospital, UK; and Department of Physical Medicine and Rehabilitation (A.K.W.), University of Pittsburgh, PA. ascher@usuhs.mil.
G Webster RossFrom the Department of Preventive Medicine and Biometrics (A.I.S.), Uniformed Services University, Bethesda; National Institute on Aging (A.I.S., M.G., L.J.L.), Laboratory of Epidemiology and Population Sciences, Bethesda, MD; Veterans Affairs Pacific Islands Health Care System (G.W.R.), Honolulu; Pacific Health Research & Education Institute (G.W.R.), Honolulu, HI; Icelandic Heart Association (S. Sigurdsson, V.G.), Kopavogur; School of Health Sciences (L.S.G.) and Faculty of Medicine (V.G.), University of Iceland, Reykjavik; Department of Neurology (S. Sveinbjörnsdóttir), Broomfield Hospital, UK; and Department of Physical Medicine and Rehabilitation (A.K.W.), University of Pittsburgh, PA.
Sigurdur SigurdssonFrom the Department of Preventive Medicine and Biometrics (A.I.S.), Uniformed Services University, Bethesda; National Institute on Aging (A.I.S., M.G., L.J.L.), Laboratory of Epidemiology and Population Sciences, Bethesda, MD; Veterans Affairs Pacific Islands Health Care System (G.W.R.), Honolulu; Pacific Health Research & Education Institute (G.W.R.), Honolulu, HI; Icelandic Heart Association (S. Sigurdsson, V.G.), Kopavogur; School of Health Sciences (L.S.G.) and Faculty of Medicine (V.G.), University of Iceland, Reykjavik; Department of Neurology (S. Sveinbjörnsdóttir), Broomfield Hospital, UK; and Department of Physical Medicine and Rehabilitation (A.K.W.), University of Pittsburgh, PA.
Melissa GarciaFrom the Department of Preventive Medicine and Biometrics (A.I.S.), Uniformed Services University, Bethesda; National Institute on Aging (A.I.S., M.G., L.J.L.), Laboratory of Epidemiology and Population Sciences, Bethesda, MD; Veterans Affairs Pacific Islands Health Care System (G.W.R.), Honolulu; Pacific Health Research & Education Institute (G.W.R.), Honolulu, HI; Icelandic Heart Association (S. Sigurdsson, V.G.), Kopavogur; School of Health Sciences (L.S.G.) and Faculty of Medicine (V.G.), University of Iceland, Reykjavik; Department of Neurology (S. Sveinbjörnsdóttir), Broomfield Hospital, UK; and Department of Physical Medicine and Rehabilitation (A.K.W.), University of Pittsburgh, PA.
Larus S GudmundssonFrom the Department of Preventive Medicine and Biometrics (A.I.S.), Uniformed Services University, Bethesda; National Institute on Aging (A.I.S., M.G., L.J.L.), Laboratory of Epidemiology and Population Sciences, Bethesda, MD; Veterans Affairs Pacific Islands Health Care System (G.W.R.), Honolulu; Pacific Health Research & Education Institute (G.W.R.), Honolulu, HI; Icelandic Heart Association (S. Sigurdsson, V.G.), Kopavogur; School of Health Sciences (L.S.G.) and Faculty of Medicine (V.G.), University of Iceland, Reykjavik; Department of Neurology (S. Sveinbjörnsdóttir), Broomfield Hospital, UK; and Department of Physical Medicine and Rehabilitation (A.K.W.), University of Pittsburgh, PA.
Sigurlaug SveinbjörnsdóttirFrom the Department of Preventive Medicine and Biometrics (A.I.S.), Uniformed Services University, Bethesda; National Institute on Aging (A.I.S., M.G., L.J.L.), Laboratory of Epidemiology and Population Sciences, Bethesda, MD; Veterans Affairs Pacific Islands Health Care System (G.W.R.), Honolulu; Pacific Health Research & Education Institute (G.W.R.), Honolulu, HI; Icelandic Heart Association (S. Sigurdsson, V.G.), Kopavogur; School of Health Sciences (L.S.G.) and Faculty of Medicine (V.G.), University of Iceland, Reykjavik; Department of Neurology (S. Sveinbjörnsdóttir), Broomfield Hospital, UK; and Department of Physical Medicine and Rehabilitation (A.K.W.), University of Pittsburgh, PA.
Amy K WagnerFrom the Department of Preventive Medicine and Biometrics (A.I.S.), Uniformed Services University, Bethesda; National Institute on Aging (A.I.S., M.G., L.J.L.), Laboratory of Epidemiology and Population Sciences, Bethesda, MD; Veterans Affairs Pacific Islands Health Care System (G.W.R.), Honolulu; Pacific Health Research & Education Institute (G.W.R.), Honolulu, HI; Icelandic Heart Association (S. Sigurdsson, V.G.), Kopavogur; School of Health Sciences (L.S.G.) and Faculty of Medicine (V.G.), University of Iceland, Reykjavik; Department of Neurology (S. Sveinbjörnsdóttir), Broomfield Hospital, UK; and Department of Physical Medicine and Rehabilitation (A.K.W.), University of Pittsburgh, PA.
Vilmundur GudnasonFrom the Department of Preventive Medicine and Biometrics (A.I.S.), Uniformed Services University, Bethesda; National Institute on Aging (A.I.S., M.G., L.J.L.), Laboratory of Epidemiology and Population Sciences, Bethesda, MD; Veterans Affairs Pacific Islands Health Care System (G.W.R.), Honolulu; Pacific Health Research & Education Institute (G.W.R.), Honolulu, HI; Icelandic Heart Association (S. Sigurdsson, V.G.), Kopavogur; School of Health Sciences (L.S.G.) and Faculty of Medicine (V.G.), University of Iceland, Reykjavik; Department of Neurology (S. Sveinbjörnsdóttir), Broomfield Hospital, UK; and Department of Physical Medicine and Rehabilitation (A.K.W.), University of Pittsburgh, PA.
Lenore J LaunerFrom the Department of Preventive Medicine and Biometrics (A.I.S.), Uniformed Services University, Bethesda; National Institute on Aging (A.I.S., M.G., L.J.L.), Laboratory of Epidemiology and Population Sciences, Bethesda, MD; Veterans Affairs Pacific Islands Health Care System (G.W.R.), Honolulu; Pacific Health Research & Education Institute (G.W.R.), Honolulu, HI; Icelandic Heart Association (S. Sigurdsson, V.G.), Kopavogur; School of Health Sciences (L.S.G.) and Faculty of Medicine (V.G.), University of Iceland, Reykjavik; Department of Neurology (S. Sveinbjörnsdóttir), Broomfield Hospital, UK; and Department of Physical Medicine and Rehabilitation (A.K.W.), University of Pittsburgh, PA.

Funding

AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
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Intramural NIH HHSNIA NIH HHS N01-AG-12100
6 · The paper itself

Abstract

objectiveIn the present study, we tested the hypothesis that having migraine in middle age is related to late-life parkinsonism and a related disorder, restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED).

methodsThe AGES-Reykjavik cohort (born 1907-1935) has been followed since 1967. Headaches were classified based on symptoms assessed in middle age. From 2002 to 2006, 5,764 participants were reexamined to assess symptoms of parkinsonism, diagnosis of Parkinson disease (PD), family history of PD, and RLS/WED.

resultsSubjects with midlife migraine, particularly migraine with aura (MA), were in later life more likely than others to report parkinsonian symptoms (odds ratio [OR]MA = 3.6 [95% CI 2.7-4.8]) and diagnosed PD (ORMA = 2.5 [95% CI 1.2-5.2]). Women with MA were more likely than others to have a parent (ORMA = 2.26 [95% CI 1.3-4.0]) or sibling (ORMA = 1.78 [95% CI 1.1-2.9]) with PD. Late-life RLS/WED was increased for headache generally. Associations were independent of cardiovascular disease and MRI-evident presumed ischemic lesions.

conclusionsThese findings suggest there may be a common vulnerability to, or consequences of, migraine and multiple indicators of parkinsonism. Additional genetic and longitudinal observational studies are needed to identify candidate pathways that may account for the comorbid constellation of symptoms.

Indexed as

AdultAgedAged, 80 and overAge FactorsBrainBrain IschemiaCardiovascular DiseasesCohort StudiesFamilyFemaleHumansMaleMiddle AgedMigraine DisordersMigraine with AuraParkinsonian Disorders

Identifiers

PMID25230997
PMCPMC4180488

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