ArticleGenetics2014
Purifying selection, drift, and reversible mutation with arbitrarily high mutation rates.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Targeted population genomics uncovers demographic history and genetic divergence in north American wild cranberry.Horticulture research · 2026Article
- Population epigenetics: deciphering DNA methylation diversity and its implications for health, disease, and evolution.Molecular biology and evolution · 2026Review
- Epimutations: raw material for evolution?The EMBO journal · 2026Review
- A gene-based model of fitness and its implications for genetic variation: linkage disequilibrium.Genetics · 2025Article
- Article
- Behavioral and Morphological Adaptations of Tortoise TickEcology and evolution · 2025Article
- A gene-based model of fitness and its implications for genetic variation: Linkage disequilibrium.bioRxiv : the preprint server for biology · 2025Article
- Methylomes Reveal Recent Evolutionary Changes in Populations of Two Plant Species.Genome biology and evolution · 2025Article
- Epigenetic variation in light of population genetic practice.Nature communications · 2025Review
- Article
- Evolution beyond DNA: epigenetic drivers for evolutionary change?BMC biology · 2023Article
- Article
- How Can We Resolve Lewontin's Paradox?Genome biology and evolution · 2022Article
- Gene Body Methylation in Plants: Mechanisms, Functions, and Important Implications for Understanding Evolutionary Processes.Genome biology and evolution · 2022Review
- Fisher's historic 1922 paper On the dominance ratio.Genetics · 2022Article
- Epimutations Define a Fast-Ticking Molecular Clock in Plants.Trends in genetics : TIG · 2021Review
- Article
- Evolutionary and functional genomics of DNA methylation in maize domestication and improvement.Nature communications · 2020Article
- Determinants of genetic variation across eco-evolutionary scales in pinnipeds.Nature ecology & evolution · 2020Article
- The determinants of genetic diversity in butterflies.Nature communications · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some species exhibit very high levels of DNA sequence variability; there is also evidence for the existence of heritable epigenetic variants that experience state changes at a much higher rate than sequence variants. In both cases, the resulting high diversity levels within a population (hyperdiversity) mean that standard population genetics methods are not trustworthy. We analyze a population genetics model that incorporates purifying selection, reversible mutations, and genetic drift, assuming a stationary population size. We derive analytical results for both population parameters and sample statistics and discuss their implications for studies of natural genetic and epigenetic variation. In particular, we find that (1) many more intermediate-frequency variants are expected than under standard models, even with moderately strong purifying selection, and (2) rates of evolution under purifying selection may be close to, or even exceed, neutral rates. These findings are related to empirical studies of sequence and epigenetic variation.
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