ArticleJapanese journal of ophthalmology2014
Evaluation of corneal damage caused by iodine preparations using human corneal epithelial cells.
Article in Japanese journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Long-term Impact of Intravitreal Injections on the ocular surface; a 2-year follow-up study.Frontiers in ophthalmology · 2026Trial
- The effect of punctal plugs in reducing ocular surface irritation after povidone-iodine preparation of intravitreal injection-a randomized trial.Eye (London, England) · 2022Trial
- Comparative study of topical regimen for adenoviral kearoconjunctivitis by 0.1% fluorometholone with and without polyvinyl alcohol iodine.Japanese journal of ophthalmology · 2021Trial
- Antiseptic Efficacy and Ocular Surface Toxicity of Povidone-Iodine and Chlorhexidine for Endophthalmitis Isolates.Investigative ophthalmology & visual science · 2026Article
- Transcorneal aspiration for management of primary iris cysts in the standing horse.Veterinary medicine and science · 2024Article
- Efficacy and Safety of Preoperative Prophylaxis in Cataract Surgery with Combined Topical Antiseptics: A Microbiological Study.Ophthalmology and therapy · 2024Article
- Evaluation of the Possible Influence of Povidone Iodine (PVI) Solution and Polyhexanide (PHMB) on Wound Healing in Corneal Epithelial Regeneration.Journal of clinical medicine · 2024Article
- Evaluation of anti-adenoviral effects of the polyvinyl alcohol iodine ophthalmic solution.Japanese journal of ophthalmology · 2024Article
- Oxidative stress in the eye and its role in the pathophysiology of ocular diseases.Redox biology · 2023Review
- Antiseptics and the Ocular Surface: In Vitro Antimicrobial Activity and Effects on Conjunctival and Corneal Epithelial Cells of a New Liposomal Ocular Spray Containing BiosecurOphthalmology and therapy · 2022Article
- The Effect of Past Cataract Surgery within the Medium to Long-Term Period on Patients with Dry Eye Disease.Journal of clinical medicine · 2022Article
- Evaluation of Retinal Function and Pathology After Intravitreal Injection of Povidone-Iodine and Polyvinyl Alcohol-Iodine in Rabbits.Translational vision science & technology · 2020Article
- Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture.BMJ open ophthalmology · 2020Article
- Polyvinyl alcohol-iodine induced corneal epithelial injury in vivo and its protection by topical rebamipide treatment.PloS one · 2018Article
- The effect of intravitreal injections on dry eye, and proposed management strategies.Clinical ophthalmology (Auckland, N.Z.) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the cytotoxicity of povidone-iodine solution (PVP-I) with that of polyvinyl alcohol-iodine solution (PAI) for ophthalmic use.
methodsCells of the human corneal epithelial cell line HCE-T were exposed to various dilutions of PVP-I or PAI, and the cytotoxicity of these two antiseptics was evaluated. The relative toxicities of PVP-I and PAI were also investigated following the inactivation of iodine by achromatization with sodium thiosulfate.
resultsPVP-I and PAI had equivalent antiseptic effects, but the cytotoxicity of PVP-I diluted 16-fold was higher than that of PAI diluted 6-fold. Following inactivation of iodine with sodium thiosulfate, the cytotoxicity of PVP-I remained concentration dependent, whereas PAI exhibited a low toxicity that was similar to the effect of saline on cell viability. Exposure to lauromacrogol, a surfactant used in PVP-I, in solution at concentrations of 1-1000 mg/mL clearly resulted in corneal cytotoxicity. The PVP-I and PAI solutions had a pH value of 4.0 and 5.2, respectively. HCE-T cells were significantly more viable at pH 7 than at pH 1-6.
conclusionTo avoid corneal damage, preoperative antisepsis of the surgical field should be accomplished with PAI diluted 6-fold, rather than with PVP-I diluted 16-fold. The toxicity of the iodine compound stems primarily from the available iodine concentration and partly from its pH, surfactant and osmolality. Further clinical investigations are required in order to determine the optimal concentrations for use.
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Registered trials
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