Evidence map›Paper›PMID 25230895›Full record

ArticleInternational journal of computer assisted radiology and surgery2015

Computer-assisted, Le Fort-based, face-jaw-teeth transplantation: a pilot study on system feasiblity and translational assessment.

Ryan J Murphy, Chad R Gordon, Ehsan Basafa, Peter Liacouras, Gerald T Grant, Mehran Armand

Abstract read
In one paragraph

Article in International journal of computer assisted radiology and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ryan J MurphyResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA.
Chad R Gordon
Ehsan Basafa
Peter Liacouras
Gerald T Grant
Mehran Armand
Johns Hopkins University · USJohns Hopkins University Applied Physics Laboratory · USMemorial Medical Center · US

Funding

Institute for Clinical and Translational ResearchUL1TR000424 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2012 to 2012
$6.0M
Computer-Assisted Orthopaedic Surgery with Intra-Operative Biomechanical GuidanceR01EB006839 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ARMAND, MEHRAN · 2007 to 2010
$1.5M
NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1TR000424-06NIBIB NIH HHS R01 EB006839
6 · The paper itself

Abstract

purposeLe Fort-based face-jaw-teeth transplantation (FJTT) attempts to marry bone and teeth geometry of size-mismatched face-jaw-teeth segments to restore function and form due to severe mid-facial trauma. Recent development of a computer-assisted planning and execution (CAPE) system for Le Fort-based FJTT in a pre-clinical swine model offers preoperative planning, and intraoperative navigation. This paper addresses the translation of the CAPE system to human anatomy and presents accuracy results.

methodsSingle-jaw, Le Fort-based FJTTs were performed on plastic models, one swine and one human, and on a human cadaver. Preoperative planning defined the goal placement of the donor's Le Fort-based FJTT segment on the recipient. Patient-specific navigated cutting guides helped achieve planned osteotomies. Intraoperative cutting guide and donor fragment placement were compared with postoperative computed tomography (CT) data and the preoperative plan.

resultsIntraoperative measurement error with respect to postoperative CT was less than 1.25 mm for both mock transplants and 3.59 mm for the human cadaver scenario. Donor fragment placement (as compared to the planned position) was less accurate for the human model test case (2.91 mm) compared with the swine test (2.25 mm) and human cadaver (2.26 mm).

conclusionThe results indicate the viability of the CAPE system for assisting with Le Fort-based FJTT and demonstrate the potential in human surgery. This system offers a new path forward to achieving improved outcomes in Le Fort-based FJTT and can be modified to assist with a variety of other surgeries involving the head, neck, face, jaws and teeth.

Indexed as

AnimalsCephalometryFacial TransplantationFeasibility StudiesHumansJawOsteotomyPatient Care PlanningPilot ProjectsSurgery, Computer-AssistedSwineTomography, X-Ray ComputedTooth

Identifiers

PMID25230895
PMCPMC4480220
OpenAlexW2002445407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.