Evidence map›Paper›PMID 25230851›Full record

Observational studyHIV medicine2015

Prevalence and correlates of obstructive sleep apnoea among patients with and without HIV infection.

K M Kunisaki, K M Akgün, D A Fiellin, C L Gibert, J W Kim, D Rimland, M C Rodriguez-Barradas, H K Yaggi, K Crothers

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in HIV medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Diagnostic performance of screening tools for the detection of obstructive sleep apnea in people living with HIV.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  7. Methods for home-based self-applied polysomnography: the Multicenter AIDS Cohort Study.Sleep advances : a journal of the Sleep Research Society · 2022
    Article
  8. Pathogenesis of obstructive sleep apnea in people living with HIV.Journal of applied physiology (Bethesda, Md. : 1985) · 2021
    Article
  9. Article
  10. Article
  11. Obstructive Sleep Apnea and Pain Intensity in Young Adults.Annals of the American Thoracic Society · 2020
    Article
  12. Review
  13. Effect of the duration of protease inhibitor therapy in HIV-infected individuals on the severity of obstructive sleep apnea.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019
    Article
  14. Article
  15. Article
  16. A Wake-up Call for Human Immunodeficiency Virus (HIV) Providers: Obstructive Sleep Apnea in People Living With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

K M KunisakiMinneapolis VA Health Care System, Minneapolis, MN, USA; University of Minnesota, Minneapolis, MN, USA.
K M Akgün
D A Fiellin
C L Gibert
J W Kim
D Rimland
M C Rodriguez-Barradas
H K Yaggi
K Crothers
Yale University · USEmory University · USJames J. Peters VA Medical Center · USMichael E. DeBakey VA Medical Center · USMinneapolis VA Health Care System · USUniversity of Washington · USWashington DC VA Medical Center · US

Funding

Alcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Longitudinal Studies of HIV-Associated Lung Infections and ComplicationsR01HL090342 · NHLBI · YALE UNIVERSITY · PI CROTHERS, KRISTINA ANNE · 2007 to 2011
$4.0M
Alcohol Associated Outcomes Among HIV+/-Aging VeteransR01AA013566 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JUSTICE, AMY CAROLINE · 2001 to 2002
$1.6M
NHLBI NIH HHS R01 HL090342NHLBI NIH HHS R01-HL090342NIAAA NIH HHS R01 AA013566NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U01-AA020790NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U10-AA13566NIAAA NIH HHS U24 AA020794NIAAA NIH HHS U24-AA020794
6 · The paper itself

Abstract

objectivesIn HIV-uninfected populations, obstructive sleep apnoea (OSA) is commonly associated with cardiovascular disease, metabolic syndrome, and cognitive impairment. These comorbidities are common in HIV-infected patients, but there are scarce data regarding OSA in HIV-infected patients. Therefore, we examined the prevalence and correlates of OSA in a cohort of HIV-infected and uninfected patients.

methodsAn observational cohort study was carried out. Electronic medical record and self-report data were examined in patients enrolled in the Veterans Aging Cohort Study (VACS) between 2002 and 2008 and followed until 2010. The primary outcome was OSA diagnosis, determined using International Classification of Diseases, 9th edition (ICD-9) codes, in HIV-infected compared with uninfected individuals. We used regression analyses to determine the association between OSA diagnosis, symptoms and comorbidities in adjusted models.

resultsOf 3683 HIV-infected and 3641 uninfected patients, 143 (3.9%) and 453 (12.4%) had a diagnosis of OSA (p<0.0001), respectively. HIV-infected patients were more likely to report symptoms associated with OSA such as tiredness and fatigue. Compared with uninfected patients with OSA, HIV-infected patients with OSA were younger, had lower body mass indexes (BMIs), and were less likely to have hypertension. In models adjusting for these traditional OSA risk factors, HIV infection was associated with markedly reduced odds of OSA diagnosis (odds ratio 0.48; 95% confidence interval 0.39-0.60).

conclusionsHIV-infected patients are less likely to receive a diagnosis of OSA. Future studies are needed to determine whether the lower prevalence of OSA diagnoses in HIV-infected patients is attributable to decreased screening and detection or to a truly decreased likelihood of OSA in the setting of HIV infection.

Indexed as

PolysomnographyPositive-Pressure RespirationVeteransAge FactorsBody Mass IndexCohort StudiesComorbidityFemaleHIV InfectionsHumansMaleMiddle AgedObesityOdds RatioPrevalenceRisk FactorsfatigueHIVobesityobstructivesleep apnoeasleep apnoea syndromes

Identifiers

PMID25230851
PMCPMC4300288
OpenAlexW1898541940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.