Evidence map›Paper›PMID 25230669›Full record

ArticleNature2014

GATM gene variants and statin myopathy risk.

D F Carr, A Alfirevic, R Johnson, H Chinoy, T van Staa, M Pirmohamed

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Nature, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Article
  9. Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy.International journal of molecular sciences · 2021
    Review
  10. Review
  11. Effects of statins on mitochondrial pathways.Journal of cachexia, sarcopenia and muscle · 2021
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Treatment Options for Statin-Associated Muscle Symptoms.Deutsches Arzteblatt international · 2015
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

D F CarrWolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, 1-5 Brownlow Street, Liverpool L69 3GL, UK.
A AlfirevicWolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, 1-5 Brownlow Street, Liverpool L69 3GL, UK.
R JohnsonWolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, 1-5 Brownlow Street, Liverpool L69 3GL, UK.
H ChinoyNIHR Manchester Musculoskeletal Biomedical Research Unit, Institute of Inflammation and Repair, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
T van StaaHealth eResearch Centre, Farr Institute for Health Informatics Research, University of Manchester, 1.311 Jean McFarlane Building, Oxford Road, Manchester M13 9PL, UK.
M PirmohamedWolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, 1-5 Brownlow Street, Liverpool L69 3GL, UK.

Funding

Medical Research Council MC_PC_13042Medical Research Council MC_QA137929Medical Research Council MR/K006665/1Medical Research Council MR/L006758/1Versus Arthritis 18474
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AmidinotransferasesGene Expression RegulationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMuscular DiseasesQuantitative Trait LociSimvastatinAmidinotransferasesHydroxymethylglutaryl-CoA Reductase InhibitorsSimvastatin

Identifiers

PMID25230669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.